Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning.
Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning.
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DOI：
10.1016/j.tcb.2009.01.001
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发表时间：
2009-03
影响因子：
19
通讯作者：
Gu, Chenghua
中科院分区：
文献类型：
--
作者：
Gelfand, Maria V.;Hong, Shangyu;Gu, Chenghua
神经系统和血管系统都是分支复杂的系统，它们的正常发育需要神经和血管的精心指导。最近认识到，共同的配体受体对用于指导两个系统的模式化，这引发了是否在两个系统中使用类似的信号通路的问题。这篇综述强调了最近的进展，在我们的理解的相似性和差异的细胞内信号转导机制的下游的semaphorins，ephrins，和VEGF在神经元和内皮细胞在神经和血管的发展。我们提出的证据表明，类似的细胞内信号转导原则的细胞骨架调节用于控制神经和血管的指导，而在神经元和内皮细胞中使用的特定分子往往是不同的。
The nervous and vascular systems are both exquisitely branched and complicated systems and their proper development requires careful guidance of nerves and vessels. The recent realization that common ligand-receptor pairs are used in guiding the patterning of both systems has prompted the question of whether similar signaling pathways are used in both systems. This review highlights recent progress in our understanding of the similarities and differences in the intracellular signaling mechanisms downstream of semaphorins, ephrins, and VEGF in neurons and endothelial cells during neural and vascular development. We present evidence that similar intracellular signaling principles underlying cytoskeletal regulation are used to control neural and vascular guidance, while the specific molecules used in neurons and endothelial cells are often different.
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影响因子：
4.8
作者：
Basile, John R.;Gavard, Julie;Gutkind, J. Silvio
通讯作者：
Gutkind, J. Silvio
影响因子：
25
作者：
Hoogenraad, CC;Milstein, AD;Sheng, M
通讯作者：
Sheng, M
影响因子：
--
作者：
Fazzari P;Penachioni J;Gianola S;Rossi F;Eickholt BJ;Maina F;Alexopoulou L;Sottile A;Comoglio PM;Flavell RA;Tamagnone L
通讯作者：
Tamagnone L
影响因子：
4.1
作者：
Groeger, Gillian;Nobes, Catherine D.
通讯作者：
Nobes, Catherine D.
影响因子：
20.3
作者：
Acevedo, Lisette M.;Barillas, Samuel;Cheresh, David A.
通讯作者：
Cheresh, David A.