From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics
From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics
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DOI：
10.1023/a:1024918525818
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发表时间：
2003-01-01
影响因子：
2.6
通讯作者：
Benham, C
中科院分区：
文献类型：
--
作者：
Bode, J;Goetze, S;Benham, C
真核基因组通过与传统上被称为核基质的支持结构的连接，在功能上被划分为染色质结构域。目前的证据表明了这种实体的动态，这需要调解这种相互作用的元素的特殊性质。最重要的是，这是由所谓的“质量结合现象”实现的，通过这种现象，支架/基质附着区域(S/MARS)与无处不在的因素可逆地联系在一起。最近的研究和新技术表明，这些接触可以通过调节器以及与增强子和基因位点控制区的特定相互作用来改变。
Eukaryotic genomes are functionally compartmentalized into chromatin domains by their attachment to a supporting structure that has traditionally been termed the nuclear matrix. Present evidence indicates the dynamics of this entity, which requires particular properties of the elements that mediate this kind of interaction. Above all, this is enabled by the so-called 'mass binding phenomenon' by which scaffold/matrix-attachment regions (S/MARs) reversibly associate with ubiquitous factors. Recent investigations and novel techniques have shown that these contacts can be altered by modulators as well as by specific interactions with the components of enhancers and locus control regions.