Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study
Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study
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DOI：
10.1111/1471-0528.15799
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发表时间：
2020-01-01
影响因子：
5.8
通讯作者：
Madan, J. C.
中科院分区：
文献类型：
--
作者：
Coker, M. O.;Hoen, A. G.;Madan, J. C.
目的评价产时抗生素及其特定类别对婴儿第一年肠道菌群的潜在影响。设计对新罕布什尔州出生队列研究（NHBCS）中婴儿的前瞻性研究。设置农村新罕布什尔州，美国。人口或样本来自NHBCS的266名足月婴儿。方法从住院病历中提取产程及分娩期抗生素使用情况。在6周和1岁时收集的粪便样本通过16S rRNA测序和样本子集的宏基因组学分析进行表征。暴露母亲在分娩和分娩期间暴露于抗生素。主要结果测量粪便样本的分类学和功能概况。结果婴儿在分娩期间暴露于抗生素，特别是两种或多种抗生素类，与6周时较低的微生物多样性评分以及独特的细菌群落独立相关（GUnifrac，P = 0.02）。1岁时，仅使用青霉素组的婴儿a多样性评分显著低于未使用产时抗生素的婴儿。在出生后的第一年内，分娩期接触青霉素与包括拟杆菌在内的几个分类群的显著较低增长相关，头孢菌素的使用与双歧杆菌随时间的显著较低增长相关，多类组中的婴儿经历了差异韦荣球菌的显著较高增长。结论我们的研究结果表明，分娩期抗生素改变了婴儿肠道微生物组的发育轨迹，并且特定的抗生素类型可能影响群落组成、多样性和关键免疫训练分类群。
Objective To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.Design Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).Settings Rural New Hampshire, USA.Population or sample Two hundred and sixty-six full-term infants from the NHBCS. Methods Intrapartum antibiotic use during labour and delivery was abstracted from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.Exposures Maternal exposure to antibiotics during labour and delivery.Main outcome measure Taxonomic and functional profiles of faecal samples.Results Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin-only group had significantly lower a diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi-class group experienced a significantly higher increase in Veillonella dispar.Conclusions Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.