Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes.
Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes.
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DOI：
10.1152/ajpregu.00680.2011
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发表时间：
2012-04
期刊：
影响因子：
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通讯作者：
Takeshi Suzuki;Y. Sugiyama;B. Yates
中科院分区：
文献类型：
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作者：
Takeshi Suzuki;Y. Sugiyama;B. Yates
臂旁核和邻近的Köliker-Ehrman（PBN/KF）核在将内脏传入输入传递到下丘脑和边缘系统中起关键作用，因此被认为参与产生胃肠道（GI）信号引起的恶心和情感反应。此外，PBN/KF区域接收来自前庭系统的输入，并可能介导与晕动病相关的不适。然而，以前的研究并没有考虑GI和前庭输入是否收敛于相同的PBN/KF神经元，如果是这样，GI信号是否改变了细胞对身体运动的反应。本研究在去脑猫中进行，测试了以下假设：胃内注射硫酸铜，通过刺激胃粘膜来刺激呕吐，修改PBN/KF神经元对激活前庭受体的垂直平面旋转的敏感性。胃内硫酸铜产生的PBN/KF单位，其发射率被修改的管理的化合物的垂直平面旋转的响应增益的70%的中位数变化; 16个单位的响应增益增加，17个单位的下降。结果往往是戏剧性的：在测试的51个神经元中，有13个只在注射硫酸铜后才对旋转产生反应，而另外10个只在给药前才有反应。这些数据表明，PBN/KF神经元的一个子集，其活动被致炎性刺激改变，也对身体运动作出反应，并且胃粘膜的刺激可以导致单位对前庭输入的敏感性放大或降低。这一发现意味着恶心和前庭刺激的情感反应可能会被来自胃肠道系统的呕吐信号所改变。
The parabrachial and adjacent Kölliker-Fuse (PBN/KF) nuclei play a key role in relaying visceral afferent inputs to the hypothalamus and limbic system and are, thus, believed to participate in generating nausea and affective responses elicited by gastrointestinal (GI) signals. In addition, the PBN/KF region receives inputs from the vestibular system and likely mediates the malaise associated with motion sickness. However, previous studies have not considered whether GI and vestibular inputs converge on the same PBN/KF neurons, and if so, whether the GI signals alter the responses of the cells to body motion. The present study, conducted in decerebrate cats, tested the hypothesis that intragastric injection of copper sulfate, which elicits emesis by irritating the stomach lining, modifies the sensitivity of PBN/KF neurons to vertical plane rotations that activate vestibular receptors. Intragastric copper sulfate produced a 70% median change in the gain of responses to vertical plane rotations of PBN/KF units, whose firing rate was modified by the administration of the compound; the response gains for 16 units increased and those for 17 units decreased. The effects were often dramatic: out of 51 neurons tested, 13 responded to the rotations only after copper sulfate was injected, whereas 10 others responded only before drug delivery. These data show that a subset of PBN/KF neurons, whose activity is altered by a nauseogenic stimulus also respond to body motion and that irritation of the stomach lining can either cause an amplification or reduction in the sensitivity of the units to vestibular inputs. The findings imply that nausea and affective responses to vestibular stimuli may be modified by the presence of emetic signals from the GI system.