Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia.
Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia.
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线粒体抗氧化剂可保护IEX-1缺乏的小鼠免受内毒素血症期间器官损伤。
DOI：
10.1016/j.intimp.2014.10.019
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发表时间：
2014-12
影响因子：
5.6
通讯作者：
Wu MX
中科院分区：
文献类型：
--
作者：
Ramsey H;Wu MX
Sepsis, a leading cause of mortality in intensive care units worldwide, is often a result of overactive and systemic inflammation following serious infections. We found that mice lacking immediate early responsive gene X-1 (IEX-1) were prone to lipopolysaccharide (LPS) -induced endotoxemia. A nonlethal dose of LPS provoked numerous aberrations in IEX-1 knockout (KO) mice including pancytopenia, increased serum aspartate aminotransferase (AST), and lung neutrophilia, concurrent with liver and kidney damage, followed by death. Given these results, in conjunction with a proven role for IEX-1 in the regulation of reactive oxygen species (ROS) homeostasis during stress, we pre-treated IEX-1 KO mice with Mitoquinone (MitoQ), a mitochondrion-based antioxidant prior to LPS injection. The treatment significantly reduced ROS formation in circulatory cells and protected against pancytopenia and multiple organ failure, drastically increasing the survival rate of IEX-1 KO mice challenged by this low dose of LPS. This study confirms significant contribution of mitochondrial ROS to the etiology of sepsis.
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
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作者：
Marchi, L. F.;Sesti-Costa, R.;Mantovani, B.
通讯作者：
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DOI：
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发表时间：
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期刊：
NEUTROPHIL METHODS AND PROTOCOLS, 2ND EDITION
影响因子：
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作者：
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通讯作者：
El-Benna, Jamel
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
3.4
作者：
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