Reproductive Biology and Endocrinology Tgf-beta Expression during Rat Pregnancy and Activity on Decidual Cell Survival
Reproductive Biology and Endocrinology Tgf-beta Expression during Rat Pregnancy and Activity on Decidual Cell Survival
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发表时间：
2005
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通讯作者：
Carl Shooner;Pierre-Luc Caron;Guylaine Fréchette-Frigon;Valérie Leblanc;Marie-Claude Déry;E. Asselin
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作者：
Carl Shooner;Pierre-Luc Caron;Guylaine Fréchette-Frigon;Valérie Leblanc;Marie-Claude Déry;E. Asselin
背景：在大鼠妊娠早期，小胚胎的滋养细胞与子宫内膜连接，上皮细胞发生凋亡。接近妊娠结束时，还观察到基底蜕膜（DB）消退（从第14天至第20天）。然而，很少有人知道的细胞内和分子机制参与细胞凋亡的调节在怀孕期间的子宫。本研究的目的是调查的存在和发育表达的转化生长因子-β亚型（TGF-β众所周知的分化因子）在整个怀孕期间的大鼠子宫内膜和它的作用在体外培养的子宫内膜间质细胞。
Background: During early rat pregnancy, trophoblast of the tiny embryo joins with the endometrium and epithelial cells undergo apoptosis. Near the end of pregnancy, regression of the decidua basalis (DB) is also observed (from day 14 to 20). However, little is known about the intra-cellular and molecular mechanisms involved in apoptosis regulation in the uterus during pregnancy. The objective of the present study was to investigate the presence and the developmental expression of transforming growth factor-beta isoforms (TGF-beta well known differentiation factor) in the rat endometrium throughout pregnancy and its action in vitro using cultured endometrial stromal cells.