Pediatric Underdosing of Efavirenz: A Pharmacokinetic Study in Uganda
Pediatric Underdosing of Efavirenz: A Pharmacokinetic Study in Uganda
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DOI：
10.1097/qai.0b013e318235e560
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发表时间：
2011-12-01
影响因子：
3.6
通讯作者：
Walker, A. Sarah
中科院分区：
文献类型：
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作者：
Fillekes, Quirine;Natukunda, Eva;Walker, A. Sarah
Objectives: To evaluate international pediatric efavirenz dosing recommendations using full pharmacokinetic (PK) information.Design: Open-label, multicenter, PK study.Methods: Forty-one HIV-infected Ugandan children (3-12 years) on efavirenz + lamivudine + abacavir were enrolled in a study of twice-daily to once-daily lamivudine + abacavir 36 weeks after antiretroviral therapy initiation in the ARROW trial. Once-daily efavirenz doses were 200, 250, 300, 350 mg for children weighing 10 to
