Long-term effects of prenatal stress and handling on metabolic parameters: Relationship to corticosterone secretion response
Long-term effects of prenatal stress and handling on metabolic parameters: Relationship to corticosterone secretion response
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DOI：
10.1016/0006-8993(95)01459-4
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发表时间：
1996-03-18
期刊：
影响因子：
2.9
通讯作者：
Simon, H
中科院分区：
文献类型：
--
作者：
Vallee, M;Mayo, W;Simon, H
产前和产后环境对下丘脑-垂体-肾上腺（HPA）轴的应激反应具有长期影响。在这项研究中，产前和产后的操作和糖皮质激素分泌的相关变化的长期影响，在成年大鼠代谢参数进行了检查。测量血糖水平、体重和基础摄食行为。我们发现，产前和产后环境的修改对这些参数有相反的长期影响，除了血糖，这是增加产前应激动物。虽然这些现象背后的机制仍有待阐明，观察表明，围产期的操作有长期的影响代谢功能相关的HPA活动。
The prenatal and postnatal environment exerts a long-term influence on the stress-response of the hypothalamic-pituitary-adrenal (HPA) axis. In this study, the long-term effects of prenatal and postnatal manipulations and their related changes on glucocorticoid secretion were examined on metabolic parameters in adult rats. Plasma glucose levels, body weight and basal feeding behavior were measured. We show that modifications of the prenatal and postnatal environment have opposite long-term effects on these parameters, except for blood glucose, which was increased in prenatally stressed animals. Although the mechanisms underlying these phenomena remain to be elucidated, the observations show that perinatal manipulations have long-term effects on metabolic functions related to HPA activity.