Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications.
Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications.
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DOI：
10.3791/53117
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
Jonah A. Kaplan;M. Grinstaff
中科院分区：
文献类型：
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作者：
Jonah A. Kaplan;M. Grinstaff
超疏水材料的表面具有永久或亚稳定的非润湿状态，在许多生物医学和工业应用中具有重要意义。在这里，我们描述了以可生物降解的、生物相容的脂肪族聚酯(例如，聚己内酯和聚丙交酯-乙交酯)为主要成分，掺入由聚酯和硬脂酸酯改性的聚甘油碳酸酯组成的疏水共聚物的聚合物混合物如何产生超疏水生物材料。电纺或电喷的制造技术分别在纤维或颗粒上和内部提供了增强的表面粗糙度和孔隙率。使用低表面能的共聚掺杂剂与聚酯混合，可以稳定地电纺或电喷，从而提供了这些超疏水材料。讨论了纤维尺寸、共聚物掺杂剂组成和浓度等重要参数及其对润湿性的影响。聚合物化学和过程工程的这种结合提供了一种使用可扩展技术开发特定用途材料的通用方法，这种技术很可能可推广到更广泛的聚合物类别，用于各种应用。
Superhydrophobic materials, with surfaces possessing permanent or metastable non-wetted states, are of interest for a number of biomedical and industrial applications. Here we describe how electrospinning or electrospraying a polymer mixture containing a biodegradable, biocompatible aliphatic polyester (e.g., polycaprolactone and poly(lactide-co-glycolide)), as the major component, doped with a hydrophobic copolymer composed of the polyester and a stearate-modified poly(glycerol carbonate) affords a superhydrophobic biomaterial. The fabrication techniques of electrospinning or electrospraying provide the enhanced surface roughness and porosity on and within the fibers or the particles, respectively. The use of a low surface energy copolymer dopant that blends with the polyester and can be stably electrospun or electrosprayed affords these superhydrophobic materials. Important parameters such as fiber size, copolymer dopant composition and/or concentration, and their effects on wettability are discussed. This combination of polymer chemistry and process engineering affords a versatile approach to develop application-specific materials using scalable techniques, which are likely generalizable to a wider class of polymers for a variety of applications.