Preparation of non-woven mats from all-aqueous silk fibroin solution with electrospinning method
Preparation of non-woven mats from all-aqueous silk fibroin solution with electrospinning method
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DOI：
10.1016/j.polymer.2006.07.009
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发表时间：
2006-08-23
期刊：
影响因子：
4.6
通讯作者：
Zhu Hesun
中科院分区：
文献类型：
--
作者：
Chen Chen;Cao Chuanbao;Zhu Hesun
在本研究中，我们成功地用高浓度的稳定的再生丝素蛋白水溶液制备了非织造垫。使用扫描电子显微镜（SEM）观察纤维的形貌。使用傅里叶变换红外 (FTIR)、广角 X 射线衍射 (WAXD) 和差示扫描量热法 (DSC) 表征纤维的结构。还进行了机械测试。初生纤维中，丝素蛋白呈无规卷曲构象，断裂应力和应变分别为0.82 MPa和0.76%，而经甲醇处理后，丝素蛋白转变为含β折叠结构，断裂应力和应变分别增加至1.49 MPa和1.63%。这项研究为静电纺丝丝素蛋白提供了一种选择，无需使用有机溶剂或与任何其他聚合物混合，这对于组织工程支架的制备可能很重要。 (c) 2006 Elsevier Ltd. 保留所有权利。
In the present study, we successfully prepared non-woven mats from stable regenerated silk fibroin aqueous solution at high concentration. Scanning electronic microscope (SEM) was used to observe the morphology of the fibers. The structure of the fibers was characterized using Fourier transform infrared (FTIR), wide-angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC). The mechanical tests were also performed. In the as-spun fibers, silk fibroin was present in a random coil conformation, the stress and strain at break were 0.82 MPa and 0.76%, respectively, while after methanol treatment, the silk fibroin was transformed into a beta-sheet-containing structure, the stress and strain at break increased to 1.49 MPa and 1.63%, respectively. This study provided an option for the electrospinning of silk fibroin without using organic solvent or blending with any other polymers, which may be important in tissue engineering scaffold preparation. (c) 2006 Elsevier Ltd. All rights reserved.