Poroelastic Evaluation of Fluid Movement Through the Lacunocanalicular System
Poroelastic Evaluation of Fluid Movement Through the Lacunocanalicular System
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DOI：
10.1007/s10439-009-9706-1
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发表时间：
2009-07-01
影响因子：
3.8
通讯作者：
Zernicke, Ronald F.
中科院分区：
文献类型：
--
作者：
Goulet, Grant C.;Coombe, Dennis;Zernicke, Ronald F.
为了量化与骨液流动相关的生理参数，我们建立了一个孔弹性腔管模型。双连续体孔隙弹性模型明确地表示了管状和腔状微观结构。利用复合材料理论计算了材料的有效性能。孔隙度和渗透率分别采用毛细管模型和球壳模型对管状和腔状微观结构进行了测定。孔隙流体压力和流体剪切应力的计算响应模拟机械载荷施加在一个频率范围内。通过对流和扩散流动模拟物种运输，并纳入骨细胞对营养物质的消耗。利用计算得到的参数值，预测了实际孔隙流体压力和流体剪切应力响应，结果与前人的实验和理论研究结果一致。应力诱导的流体流动被强调为物种运输的有效手段，并证明了高强度低频载荷对骨细胞营养的重要性。这个新模型可以作为未来分层建模工作的基础，为深入了解骨的机械转导和功能适应的潜在机制提供帮助。
A poroelastic lacunocanalicular model was developed for the quantification of physiologically relevant parameters related to bone fluid flow. The canalicular and lacunar microstructures were explicitly represented by a dual-continuum poroelastic model. Effective material properties were calculated using the theory of composite materials. Porosity and permeability values were determined using capillaric and spherical-shell models for the canalicular and lacunar microstructures, respectively. Pore fluid pressure and fluid shear stress were calculated in response to simulated mechanical loading applied over a range of frequencies. Species transport was simulated with convective and diffusive flow, and osteocyte consumption of nutrients was incorporated. With the calculated parameter values, realistic pore fluid pressure and fluid shear stress responses were predicted and shown to be consistent with previous experimental and theoretical studies. Stress-induced fluid flow was highlighted as a potent means of species transport, and the importance of high-magnitude low-frequency loading on osteocyte nutrition was demonstrated. This new model can serve as the foundation for future hierarchical modeling efforts that may provide insight into the underlying mechanisms of mechanotransduction and functional adaptation of bone.