Successful sequential treatment of a patient with advanced gastrointestinal stromal tumor using four different molecularly targeted drugs.
Successful sequential treatment of a patient with advanced gastrointestinal stromal tumor using four different molecularly targeted drugs.
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使用四种不同的分子靶向药物成功序贯治疗晚期胃肠道间质瘤患者。
DOI：
10.1007/s13691-016-0250-1
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发表时间：
2016
影响因子：
0.7
通讯作者：
Ishioka C.
中科院分区：
文献类型：
--
作者：
Sugiyama S;Ishizuka M;Takahashi M;Komine K;Imai H;Saijo K;Takahashi M;Shirota H;Takahashi S;Shimodaira H;Ishioka C.
一名60岁女性因上腹疼痛入院就诊。食管胃十二指肠镜检查发现上胃体粘膜下肿瘤，随后采用部分胃切除术切除肿瘤。病理结果显示，该肿瘤为胃肠道间质瘤。经过4个月的观察，未进行任何辅助治疗，患者发现肝转移，入我院治疗。我们通过伊马替尼、尼洛替尼、舒尼替尼和瑞格非尼等序贯药物治疗成功治疗了该患者，并保持疾病控制超过 5 年。
A 60-year-old woman was admitted to a medical clinic because of epigastric pain. Esophagogastroduodenoscopy revealed a submucosal tumor in the upper gastric corpus and, the tumor was subsequently resected using partial gastrectomy. The pathological findings revealed that the tumor was a gastrointestinal stromal tumor. After 4 months of observation without any adjuvant treatment, the patient was found to have liver metastasis and she was admitted to our hospital for treatment. We successfully treated the patient through sequential drug therapies, including imatinib, nilotinib, sunitinib, and regorafenib, and maintaining disease control for more than 5 years.