Advances in targeted therapies and new promising targets in esophageal cancer.
Advances in targeted therapies and new promising targets in esophageal cancer.
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DOI：
10.18632/oncotarget.2752
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发表时间：
2015-01-30
期刊：
影响因子：
--
通讯作者：
El-Rifai W
中科院分区：
文献类型：
--
作者：
Belkhiri A;El-Rifai W
食管癌包括鳞状细胞癌和腺癌，是世界上癌症相关死亡的主要原因。值得注意的是，食管腺癌的发病率在西方世界以惊人的速度增加。不幸的是，标准的一线化学-放射治疗方法是有毒的，并且在治疗大量癌症患者中的功效有限。癌细胞的分子分析揭示了肿瘤发展和进展的关键遗传和表观遗传改变。这些发现为靶向治疗方法的出现铺平了道路。本文就食管癌靶向治疗的最新进展作一综述。这将包括一个审查药物靶向受体酪氨酸激酶和其他激酶在食管癌。将需要进一步的研究，以开发一个合理的整合这些靶向药物的组织学类型的食管癌和最佳选择的癌症患者谁最有可能受益于靶向治疗。AURKA和AXL作为食管肿瘤发生和耐药性的关键分子参与者的鉴定强烈证明了在临床试验中针对这些靶点的可用药物的评价是合理的。
Esophageal cancer, comprising squamous carcinoma and adenocarcinoma, is a leading cause of cancer-related death in the world. Notably, the incidence of esophageal adenocarcinoma has increased at an alarming rate in the Western world. Unfortunately, the standard first-line chemo-radiotherapeutic approaches are toxic and of limited efficacy in the treatment of a significant number of cancer patients. The molecular analysis of cancer cells has uncovered key genetic and epigenetic alterations underlying the development and progression of tumors. These discoveries have paved the way for the emergence of targeted therapy approaches. This review will highlight recent progress in the development of targeted therapies in esophageal cancer. This will include a review of drugs targeting receptor tyrosine kinases and other kinases in esophageal cancer. Additional studies will be required to develop a rational integration of these targeted agents with respect to histologic types of esophageal cancer and the optimal selection of cancer patients who would most likely benefit from targeted therapy. Identification of AURKA and AXL as key molecular players in esophageal tumorigenesis and drug resistance strongly justifies the evaluation of the available drugs against these targets in clinical trials.
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影响因子：
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DOI：
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发表时间：
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影响因子：
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