Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications
Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications
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DOI：
10.1016/j.jneuroim.2019.576999
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发表时间：
2019-09-15
影响因子：
3.3
通讯作者：
Shimohata, Takayoshi
中科院分区：
文献类型：
--
作者：
Kimura, Akio;Takemura, Masao;Shimohata, Takayoshi
自身免疫性胶质纤维酸性蛋白（GFAP）星形细胞病（GFAP-A）是一种皮质类固醇反应性脑膜脑脊髓炎，其发病机制尚不清楚。我们检查并比较了 GFAP-A 和其他神经系统疾病患者脑脊液 (CSF) 中细胞因子和生物标志物的水平。我们确定了 GFAP-A 急性期脑脊液样本中四种细胞因子（肿瘤坏死因子 α [TNF α]、白细胞介素 [IL]-27、IL-6 和趋化因子 [C-C 基序]配体 20）和三种生物标志物（GFAP、S100 钙结合蛋白 B 和神经丝轻链）的水平升高。此外，我们还发现脑脊液 TNF α、IL-27、IL-6 和脑脊液生物标志物之间存在显着相关性。
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNF alpha], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNF alpha, IL-27, IL-6, and CSF biological markers.