Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps.
Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps.
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DOI：
10.1111/micc.12352
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Yuan SY
中科院分区：
文献类型：
--
作者：
Meegan JE;Yang X;Coleman DC;Jannaway M;Yuan SY
中性粒细胞在宿主防御感染或损伤中发挥着重要作用。虽然中性粒细胞激活对于病原体清除和组织修复是必要的，但过度活跃的反应可能导致组织损伤和微循环障碍，这是一个涉及复杂的中性粒细胞-内皮串扰的过程。这篇综述重点介绍了有关中性粒细胞介导的信号传导和结构变化的最新研究结果，包括中性粒细胞胞外陷阱诱导的信号和结构变化，最终导致血管屏障损伤。
Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium crosstalk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.