Relationship between brainstem MRI and pathological findings in progressive supranuclear palsy - study in autopsy cases
Relationship between brainstem MRI and pathological findings in progressive supranuclear palsy - study in autopsy cases
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DOI：
10.1016/s0022-510x(97)00166-4
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发表时间：
1997-11-25
影响因子：
4.4
通讯作者：
Ujihira, N
中科院分区：
文献类型：
--
作者：
Aiba, I;Hashizume, Y;Ujihira, N
本文对8例进行性核上性麻痹（PSP）尸检病例的脑干MRI表现与病理结果的关系进行了研究。中脑水平T1加权像表现为被盖、顶盖萎缩，导水管扩张，组织学上与导水管周围灰质、四叠体板、被盖萎缩一致。在这些病变中，我们检测到神经元丢失、有髓纤维密度降低、神经胶质增生、组织稀疏和tau蛋白阳性结构，如神经纤维缠结（NFT）、神经胶质细胞缠结（GFT）和神经纤维丝。在pens水平，脑盖萎缩，脑桥基底萎缩，桥前池扩张，Tau阳性结构不仅见于脑盖，也见于脑桥基底。tau蛋白阳性结构的密度与萎缩的严重程度密切相关。T2加权像表现为中脑导水管周围病变和脑盖区高信号。在这些病变中，检测到严重的组织学结果。脑干MRI表现与PSP的组织学表现密切相关。(C)1997年Elsevier Science B.V.
The relationship between the features of MRI in brainstem and pathological findings was investigated in eight autopsy cases with progressive supranuclear palsy (PSP). Features of Tl-weighted images at midbrain level were atrophy of tegmentum and tectum, and dilatation of aqueduct, Histologically, these findings were consistent with atrophy of periaqueductal gray matter, quadrigeminal plate, and tegmentum. In these lesions, we detected neuronal loss, decrease in density of myelinated fibers, gliosis, rarefaction of tissues, and tau-positive structures such as neurofibrillary tangles (NFTs), glial fibrillary tangles (GFTs) and neuropil threads. At pens level, atrophy of tegmentum, atrophy of pontine base, and dilatation of prepontine cistern were found. Tau-positive structures were observed not only in tegmentum but also in pontine base. The density of the tau-positive structure was closely related to the severity of atrophy. Features of T2-weighted images were high intensity in the periaqueductal lesion and tegmentum in pens. In these lesions, severe histological findings were detected. The MRI features in brainstem were closely related to the histological findings as PSP. (C) 1997 Elsevier Science B.V.