Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue.
Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue.
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使用静脉注射奥曲肽（一种生长抑素类似物）成功治疗顽固性隐孢子虫腹泻。
DOI：
10.1097/00002030-199106000-00020
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Wittner,M
中科院分区：
文献类型：
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作者：
Kreinik,G;Burstein,O;Landor,M;Bernstein,L;Weiss,LM;Wittner,M
一名38岁男性艾滋病和顽固性大量腹泻，由于隐孢子虫感染，成功地治疗了静脉注射奥曲肽，生长抑素类似物。当患者每天用400 μ g静脉注射奥曲肽治疗时，腹泻量（10-12升，每天运动8-13次）减少到每天3 - 4次半成形至成形粪便。患者停止静脉高营养，恢复经口进食。他很快恢复了正常体重，现在已经恢复了正常活动。对于那些不能耐受皮下给药的患者，静脉注射奥曲肽治疗不仅可以挽救生命，而且可以显著提高生活质量。罗红霉素，一种大环内酯类抗生素，也给予该患者隐孢子虫病，但疗效未得到证实。
A 38-year-old man with AIDS and intractable large-volume diarrhea due to a cryptosporidial infection was successfully treated with intravenous octreotide, a somatostatin analogue. The volume of diarrhea, 10–12 liters with 8–13 movements per day, was reduced to three to four semi-formed to formed stools per day when the patient was treated with 400 (xg intravenous octreotide daily. The patient's intravenous hyperalimentation was discontinued and he returned to oral feeding. He quickly regained his normal weight and has now resumed his normal activites. For those patients who cannot tolerate subcutaneous administration, intravenous octreotide therapy may not only be life-saving but may also markedly increase the quality of life. Roxithromycin, a macrolide antibiotic, was also administered to this patient with cryptosporidiosis but efficacy was not demonstrated.