Correlation of Endothelin-1 Concentration in Aqueous Humor with Intraocular Pressure in Primary Open Angle and Pseudoexfoliation Glaucoma
Correlation of Endothelin-1 Concentration in Aqueous Humor with Intraocular Pressure in Primary Open Angle and Pseudoexfoliation Glaucoma
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DOI：
10.1167/iovs.12-10216
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发表时间：
2012-10-01
影响因子：
4.4
通讯作者：
Thieme, Hagen
中科院分区：
文献类型：
--
作者：
Choritz, Lars;Machert, Maren;Thieme, Hagen
目的.内皮素-1（ET-1）在青光眼患者的房水中浓度升高。动物实验的间接证据表明，ET-1可能直接影响眼内压（IOP）。本研究旨在探讨白内障和青光眼患者房水中ET-1浓度与眼压的关系。在常规白内障手术或小梁切除术期间，收集患有白内障（对照组，n = 38）、原发性开角型青光眼（POAG，n = 35）或假性剥脱性青光眼（PEXG，n = 21）且无其他眼部或全身疾病的患者的房水和血液样本。采用ET-1 ELISA试剂盒测定血浆ET-1浓度。术前通过标准Goldmann压平眼压计测量IOP。所有统计分析均使用商业预测分析软件进行。与对照组（15.0 +/- 2.9 mm Hg，4.3 +/- 2.4 pg/mL）相比，POAG（23.4 +/- 6.8 mm Hg，5.9 +/- 2.9 pg/mL）和PEGG（24.3 +/- 8.8 mm Hg，7.7 +/- 2.1 pg/mL）组的IOP和房水中ET-1浓度均显著增加。血浆ET-1浓度无差异。眼压与血浆ET-1无相关性，而与房水ET-1有显著相关性（R = 0.394，R-2 = 0.155，P < 0.001）。本研究发现眼内压与眼内液中ET-1浓度之间存在一个微小但高度显著的相关性，尽管不能由此推断出因果关系，但眼内ET-1对眼内压控制的作用值得进一步研究。（Invest Ophthalmol维斯科学。2012; 53：7336-7342）DOI：10.1167/iovs.12-10216
PURPOSE. Endothelin-1 (ET-1) has been found in elevated concentrations in the aqueous humor of glaucoma patients. Indirect evidence from animal studies suggests that ET-1 might directly influence intraocular pressure (IOP). The aim of this study was to determine whether ET-1 concentrations in aqueous humor of cataract and glaucoma patients correlate with IOP.METHODS. Aqueous humor and blood samples from patients with either cataract (control, n = 38), primary open angle glaucoma (POAG, n = 35), or pseudoexfoliation glaucoma (PEXG, n = 21), without other ocular or systemic disease, were collected during routine cataract surgery or trabeculectomy. ET-1 concentration was determined by an ET-1 ELISA kit. IOP was measured preoperatively by standard Goldmann applanation tonometry. All statistical analysis was performed using commercial predictive analytics software.RESULTS. Both IOP and ET-1 concentration in aqueous humor were significantly increased in POAG (23.4 +/- 6.8 mm Hg, 5.9 +/- 2.9 pg/mL) and PEXG (24.3 +/- 8.8 mm Hg, 7.7 +/- 2.1 pg/mL) compared with control (15.0 +/- 2.9 mm Hg, 4.3 +/- 2.4 pg/mL). No difference was detected for plasma ET-1 concentrations. IOP and ET-1 in the aqueous humor were significantly correlated (R = 0.394, R-2 = 0.155, P < 0.001), although no correlation was found between IOP and ET-1 in blood plasma or between ET-1 in aqueous humor and ET-1 in plasma.CONCLUSIONS. In this study, a small but highly significant correlation between IOP and the ET-1 concentration in the aqueous humor was found. Although no causative relationship can be deduced from this, ocular ET-1 effects on IOP control may merit further investigation. (Invest Ophthalmol Vis Sci. 2012; 53: 7336-7342) DOI: 10.1167/iovs.12-10216