The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation
The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation
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DOI：
10.1016/j.ando.2016.03.004
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发表时间：
2016-12-01
影响因子：
3.1
通讯作者：
Tang, Yubin
中科院分区：
文献类型：
--
作者：
Huang, Shan;Zou, Dajin;Tang, Yubin
目的。-探讨不对称二甲基精氨酸（ADMA）、脂联素（APN）和apelin在预测糖调节障碍（IGR）患者大血管病变中的作用。方法。-本研究共纳入210例口服糖耐量试验患者。分为糖耐量正常组（NGT, n = 42）、空腹血糖受损组（IFG, n = 36）、糖耐量受损组（IGT, n = 92，其中IGT1组44例，IGT2组48例）和ITO + IGT组（n = 40）。检测APN、apelin和ADMA水平、血压、血脂、胰岛素、体重指数（BMI）和胰岛素抵抗的稳态模型评估（HOMA-IR）。采用Gensini评分测定冠状动脉粥样硬化的严重程度和程度。结果。- IGT组和IFG + IGT组冠心病患病率和Gensini评分相似，但均高于NGT和IFG组（均P < 0.05）。与NGT和IFG组相比，IGT和IGT + IFG组APN降低，ADMA和apelin水平升高（均P < 0.05）。IGT2组2 h PG、apelin水平及Gensini评分高于IGT1组，APN水平低于IGT1组（均P < 0.05）。Gensini评分与apelin （r = 0.669）、ADMA （r = 0.764）呈正相关，与APN （r = -0.555，均P < 0.001）呈负相关。ADMA和APN是影响Gensini评分的独立因素。结论。ADMA和APN水平可能是IGR患者，特别是IGT患者大血管病变的预测因素。(C) 2016 Elsevier Masson SAS。版权所有。
Purpose. - To investigate the effects of asymmetric dimethyl-arginine (ADMA), adiponectin (APN) and apelin in predicting macroangiopathy in impaired glucose regulation (IGR) patients. Methods. - A total of 210 patients undergoing oral glucose tolerance test were included in this study. They were classified to normal glucose tolerance (NGT, n = 42), impaired fasting glucose (IFG, n = 36), impaired glucose tolerance (IGT, n = 92, including 44 IGT1 and 48 IGT2 patients) and ITO + IGT (n = 40) groups. APN, apelin and ADMA levels, blood pressure, blood lipid, insulin, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR), were detected. The severity and extent of coronary atherosclerosis were determined by the Gensini score. Results. - The prevalence of coronary heart disease and Gensini scores in IGT and IFG + IGT groups were similar but both were higher than NGT and IFG groups (all P < 0.05). Lower APN, higher ADMA and apelin levels were witnessed in IGT and IGT + IFG groups compared with NGT and IFG groups (all P < 0.05). IGT2 group had higher 2-h PG and apelin levels and Gensini scores but lower APN levels than IGT1 group (all P < 0.05). Gensini score was positively correlated with apelin (r = 0.669) and ADMA (r = 0.764), but were negatively correlated with APN (r = -0.555, all P < 0.001). ADMA and APN were the independent factors affecting Gensini score. Conclusion. - ADMA and APN levels could be predictive factors for macroangiopathy in IGR patients, especially in IGT cases. (C) 2016 Elsevier Masson SAS. All rights reserved.