Glucose metabolic analysis of musculoskeletal tumours using 18fluorine-FDG PET as an aid to preoperative planning
Glucose metabolic analysis of musculoskeletal tumours using 18fluorine-FDG PET as an aid to preoperative planning
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DOI：
10.1302/0301-620x.82b5.9824
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发表时间：
2000-07-01
影响因子：
--
通讯作者：
Takagishi, K
中科院分区：
文献类型：
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作者：
Watanabe, H;Shinozaki, T;Takagishi, K
我们用（18）氟-氟-2-脱氧-d -葡萄糖（FDG）对55例涉及肌肉骨骼系统的肿瘤患者进行了正电子发射断层扫描（PET），以评估其在手术计划中的作用。计算FDG的标准化摄取值（SUV），并将病例分为高（大于或等于1.9）和低（< 1.9）SW组，以区分恶性病变和良性病变。PET对恶性肿瘤的正确诊断敏感性为100%，特异性为76.9%，总体准确率为83.0%。转移性病变的平均SUV是原发性肉瘤的两倍（p < 0.0015）。我们的研究结果表明，SUV可能有助于区分恶性肿瘤和良性病变，然而，后者，如神经鞘瘤，具有高SUV，因此选择活检或广泛切除作为第一次手术。因此，高suv神经源性良性肿瘤的术前规划可能需要一些其他定量分析。逆转录聚合酶链反应显示，葡萄糖代谢关键酶磷酸己糖异构酶(PHI)/自分泌运动因子的RNA信息仅在FDG摄取高的病变中增强，这表明PHI信息的高表达可能与FDG在肌肉骨骼肿瘤中的积累有关。
We performed positron emission tomography (PET) with (18)fluorine-fluoro-2-deoxy-D-glucose (FDG) on 55 patients with tumours involving the musculoskeletal system in order to evaluate its role in operative planning. The standardised uptake value (SUV) of FDG was calculated and, to distinguish malignancies from benign lesions, the cases were divided into high (greater than or equal to 1.9) and low (< 1.9) SW groups.The sensitivity of PET for correctly diagnosing malignancy was 100% with a specificity of 76.9% and an overall accuracy of 83.0%. The mean SUV for metastatic lesions was twice that for primary sarcomas (p < 0.0015).Our results suggest that the SUV may be useful in differentiating malignant tumours from benign lesions, However, some of the latter, such as schwannomas, had high SUVs so that biopsy or wide resection was selected as the first operation. Thus, some other quantitative analysis may be required for preoperative planning in cases of high-SUV neurogenic benign tumours, The reverse transcription-polymerase chain reaction revealed that the RNA message of a key enzyme in glucose metabolism, phosphohexose isomerase (PHI)/autocrine motility factor, was augmented in only high FDG-uptake lesions, suggesting that a high expression of the PHI message may be associated with accumulation of FDG in musculoskeletal tumours.