Bone marrow transplantation in a child with Wiskott‐Aldrich syndrome latently infected with acyclovir‐resistant (ACVr) herpes simplex virus type 1: Emergence of foscarnet‐resistant virus originating from the ACVr virus
Bone marrow transplantation in a child with Wiskott‐Aldrich syndrome latently infected with acyclovir‐resistant (ACVr) herpes simplex virus type 1: Emergence of foscarnet‐resistant virus originating from the ACVr virus
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潜伏感染阿昔洛韦耐药 (ACVr) 单纯疱疹病毒 1 型的 Wiskott-Aldrich 综合征儿童的骨髓移植：源自 ACVr 病毒的膦甲酸耐药病毒的出现
DOI：
10.1002/jmv.10175
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发表时间：
2002
影响因子：
12.7
通讯作者：
S. Morikawa
中科院分区：
文献类型：
--
作者：
M. Saijo;Y. Yasuda;H. Yabe;S. Kato;T. Suzutani;E. De Clercq;M. Niikura;A. Maeda;I. Kurane;S. Morikawa
对一名患有先天性免疫缺陷综合征 Wiskott-Aldrich 综合征的 13 岁患者进行了人类白细胞抗原 (HLA) 匹配的无关骨髓移植 (BMT)。患者在 BMT 之前有阿昔洛韦 (ACV) 耐药 (ACVr) 1 型单纯疱疹病毒 (HSV-1) 感染史。 BMT 后，HSV-1 引起的皮肤损伤在面部和生殖肛门区域复发。开始更昔洛韦（GCV）治疗，但皮肤粘膜病变恶化。在此期间从病变中恢复的 HSV-1 分离株对 ACV 和 GCV 均具有抗药性。经证实，该 ACVr 分离株的病毒胸苷激酶 (TK) 基因与之前从患者体内分离的 ACVr 分离株具有相同的突变。改用膦甲酸（PFA）治疗后，病情得到了满意的缓解，但并未完全恢复。尽管皮肤粘膜病变有所改善，但在开始 PFA 治疗 1 个月后分离出 PFA 耐药 (PFAr) HSV-1。 PFAr HSV-1 分离株编码的病毒 TK 基因突变与 ACVr HSV-1 分离株相同。此外，PFAr 分离物还表达了一种突变的病毒 DNA 聚合酶 (DNA pol)，其 715 位的 Val 被氨基酸 (Gly) 取代。这是关于 BMT 相关 ACVr HSV-1 感染临床过程的第一份报告，该感染随后也对膦甲酸产生了耐药性。 J.医学。病毒。 68:99–104, 2002。© 2002 Wiley-Liss, Inc.
A human leukocyte antigen (HLA)‐matched unrelated bone marrow transplantation (BMT) was performed in a 13‐year‐old patient with the congenital immunodeficiency syndrome, Wiskott‐Aldrich syndrome. The patient had a history of acyclovir (ACV)‐resistant (ACVr) herpes simplex virus type 1 (HSV‐1) infections prior to BMT. After BMT, the skin lesions caused by HSV‐1 relapsed on the face and genito‐anal areas. Ganciclovir (GCV) therapy was initiated, but the mucocutaneous lesions worsened. An HSV‐1 isolate recovered from the lesions during this episode was resistant to both ACV and GCV. The ACVr isolate was confirmed to have the same mutation in the viral thymidine kinase (TK) gene as that of the previously isolated ACVr isolates from the patient. After treatment switch to foscarnet (PFA), there was a satisfactory remission but not a complete recovery. Although the mucocutaneous lesions improved, a PFA‐resistant (PFAr) HSV‐1 was isolated 1 month after the start of PFA therapy. The PFAr HSV‐1 isolate coded for the same mutation in the viral TK gene as the ACVr HSV‐1 isolates. Furthermore, the PFAr isolate also expressed a mutated viral DNA polymerase (DNA pol) with an amino acid (Gly) substitution for Val at position 715. This is the first report on the clinical course of a BMT‐associated ACVr HSV‐1 infection that subsequently developed resistance to foscarnet as well. J. Med. Virol. 68:99–104, 2002. © 2002 Wiley‐Liss, Inc.
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影响因子：
20.3
作者：
Filipovich, AH;Stone, JV;Horowitz, MM
通讯作者：
Horowitz, MM
影响因子：
5.1
作者：
SULLIVAN, KE;MULLEN, CA;WINKELSTEIN, JA
通讯作者：
WINKELSTEIN, JA
骨髓移植治疗 Wiskott-Aldrich 综合征。
影响因子：
6.2
作者：
Rimm,IJ;Rappeport,JM
通讯作者：
Rappeport,JM
影响因子：
14.9
作者：
J. Hall;Y. S. Wang;J. Pierpont;M. Berlin;S. Rundlett;S. Woodward
通讯作者：
J. Hall;Y. S. Wang;J. Pierpont;M. Berlin;S. Rundlett;S. Woodward
DOI：
10.1093/infdis/161.6.1078
发表时间：
1990-06
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
S. Safrin;T. Assaykeen;S. Follansbee;J. Mills
通讯作者：
S. Safrin;T. Assaykeen;S. Follansbee;J. Mills