Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms
Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms
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DOI：
10.1016/j.conb.2019.09.012
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发表时间：
2019-12-01
影响因子：
5.7
通讯作者：
Greer, Eric Lieberman
中科院分区：
文献类型：
--
作者：
Liberman, Noa;Wang, Simon Yuan;Greer, Eric Lieberman
DNA序列中未编码的遗传信息可以调节多种复杂的表型。然而，这种表观遗传信息是如何逃脱受精时发生的典型表观遗传消除的，以及它是如何调节行为的，目前尚不清楚。在这里，我们回顾了最近与大脑相关的跨代表观遗传的例子，并描述了可能调节非遗传信息如何传递的潜在分子机制。
Inherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related transgenerational epigenetic inheritance and delineate potential molecular mechanisms that could regulate how non-genetic information could be transmitted.