Measurements of the persistent singlet state of N2O in blood and other solvents--potential as a magnetic tracer.
Measurements of the persistent singlet state of N2O in blood and other solvents--potential as a magnetic tracer.
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DOI：
10.1002/mrm.23119
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发表时间：
2011-10
影响因子：
3.3
通讯作者：
Rizi, R. R.
中科院分区：
文献类型：
--
作者：
Ghosh, R. K.;Kadlecek, S. J.;Ardenkjaer-Larsen, J. H.;Pullinger, B. M.;Pileio, G.;Levitt, M. H.;Kuzma, N. N.;Rizi, R. R.
超极化示踪剂的发展受到核极化寿命短的限制。溶液中许多超极化剂的主要弛豫机制是由分子运动调制的分子内核偶极子-偶极子耦合引起的。先前已经证明，由于这种机制导致的核自旋弛豫可以通过将核极化储存在长寿命的单重态来消除。在N2O的情况下，储存氮核的极化已被证明可以大大增加极化寿命。通过测量溶解在各种溶剂（包括全血）中的N2O的单重态寿命，研究了利用N2O作为示踪剂的可行性。单重态寿命与纵向弛豫以及质子化和氘化溶剂之间的比较与自旋-旋转弛豫的优势一致，除了血液的情况。
The development of hyperpolarized tracers has been limited by short nuclear polarization lifetimes. The dominant relaxation mechanism for many hyperpolarized agents in solution arises from intramolecular nuclear dipole-dipole coupling modulated by molecular motion. It has been previously demonstrated that nuclear spin relaxation due to this mechanism can be removed by storing the nuclear polarization in long-lived, singlet-like states. In the case of N2O, storing the polarization of the nitrogen nuclei has been shown to substantially increase the polarization lifetime. The feasibility of utilizing N2O as a tracer is investigated by measuring the singlet-state lifetime of the N2O when dissolved in a variety of solvents including whole blood. Comparison of the singlet lifetime to longitudinal relaxation and between protonated and deuterated solvents is consistent with the dominance of spin-rotation relaxation, except in the case of blood.
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