Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study
Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study
复制标题
DOI：
10.1016/j.humpath.2005.07.022
复制
发表时间：
2005-10-01
期刊：
影响因子：
3.3
通讯作者：
Sasaki, K
中科院分区：
文献类型：
--
作者：
Kawauchi, S;Okuda, S;Sasaki, K
子宫颈大细胞神经内分泌癌（LCNEC）是世界卫生组织新修订的分类中的一个新的类别。我们报告一例子宫颈LCNEC的细胞遗传学分析比较基因组杂交（CGH）。宫颈肿瘤显示有丝分裂活动中度增加（每10个高倍视野中有8-14个有丝分裂像）和局灶性坏死，这使得与非典型类癌的鉴别成为问题。CGH分析未能检测到染色体11 q丢失，这已被报道为肺非典型类癌的特征。此外，染色体3q扩增是最显著的染色体畸变，在肺小细胞癌和LCNEC中经常检测到，但在肺典型和非典型类癌中未检测到。虽然CGH报告在子宫颈神经内分泌肿瘤中非常罕见，但特异性染色体畸变可能有助于鉴别。(c)2005年爱思唯尔公司All rights reserved.
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a newly introduced category of the revised World Health Organization classification. We reported a case of cervical LCNEC with cytogenetic analysis by comparative genomic hybridization (CGH). The cervical tumor showed moderately increased mitotic activity (8-14 mitotic figures per 10 high-power fields) and focal necrosis, which made it problematic to differentiate from atypical carcinoid. CGH analysis failed to detect chromosome 11q loss that has been reported to be characteristic of pulmonary atypical carcinoids. Furthermore, chromosome 3q amplification, which has been detected frequently in pulmonary small cell carcinomas and LCNECs but not in pulmonary typical and atypical carcinoids, was the most remarkable chromosomal aberration. Although CGH reports are extremely rare in neuroendocrine tumors of the uterine cervix, specific chromosomal aberrations may be useful in their distinction. (c) 2005 Elsevier Inc. All rights reserved.