Hypoglycemic Activity of 96% Ethanolic Extract of Andrographis paniculata Nees. and Swietenia mahagoni Jacq. Combination.
Hypoglycemic Activity of 96% Ethanolic Extract of Andrographis paniculata Nees. and Swietenia mahagoni Jacq. Combination.
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降血糖%20活性%20of%2096%%20乙醇%20提取物%20of%20穿心莲%20paniculata%20Nees.%20和%20Swietenia%20mahagoni%20Jacq.%20组合。
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Rakhmawati
中科院分区：
文献类型：
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作者：
Sukardiman;S. MuljaHadi;Herra Studiawan;F. RizaNurayu;Rakhmawati
糖尿病是一组异质性的综合征，其特征在于由胰岛素的相对或绝对缺乏引起的血糖升高。糖尿病的发病率在世界范围内迅速增长。糖尿病的药物治疗是昂贵的，并且具有许多不良反应的风险。印度尼西亚是一个丰富的商场的药用植物用于治疗糖尿病。本研究采用四氧嘧啶糖尿病小鼠模型，测定了穿心莲、桃花心木种子乙醇提取物及其配伍对糖尿病小鼠的降血糖作用。将穿心莲草药、桃花心木种子的96%乙醇提取物以及它们以1：1、1：2和2：1的比例（28 mg/20 g BW）的组合经口给予组I、II、III、IV和V，持续7天。对照药物格列本脲（0.013 mg/10 g BW）和CMC-Na也分别经口给予小鼠作为阳性和阴性对照组。与阴性对照组相比，这些提取物的施用产生血糖水平（BGL）的显著降低。穿心莲的96%乙醇提取物组合物。草药和桃花心木比例为2：1的种子表现出BGL的最大降低（250.80 mg/dl）。穿心莲和桃花心木的96%乙醇提取物的BGL分别降低了232.00 mg/dl和28.00 mg/dl。1：1和1：2的组合分别具有显著的BGL（213.60 mg/dl）和（237.60 mg/dl）。
Diabetes mellitus is a heterogeneous group of syndromes characterized by an elevation of blood glucose caused by a relative or absolute deficiency of insulin. The incidence of diabetes is growing rapidly worldwide. Drug treatment for diabetes mellitus is expensive and carries risks for many adverse effects. Indonesia is one of rich emporium of medicinal plants useful in the treatment of diabetes. This research was performed to measure the hypoglycemic activity of ethanolic extract of Andrographis paniculata herbs and Swietenia mahagoni seeds and its combination in experimentally in alloxan-induced diabetic mice. The 96% ethanolic extract of Andrographis paniculata herbs, Swietenia mahagoni seeds, and their combination with ratio 1:1, 1:2 and 2:1 (28 mg/20 g BW), was administered orally to groups I, II, III, IV and V for seven days. The reference drug glibenclamide (0.013 mg/10 g BW) and CMC-Na were also administered orally to mice as positive and negative control group respectively. Administration of those extract produced significant reduce in the blood glucose level (BGL) compared to negative control group. The 96% ethanolic extract combination of Andrographis paniculata Nees. herbs and Swietenia mahagoni Jacq. seeds with ratio 2:1 showed the biggest reduction in BGL (250.80 mg/dl). The 96% ethanolic extract of Andrographis paniculata and Swietenia mahagoni showed BGL reduction of (232.00 mg/dl) and (28.00 mg/dl) respectively. The combination with ratio 1:1 and 1:2 has significant BGL of (213.60 mg/dl) and (237.60 mg/dl) respectively.