A walk through the SMC cycle: From catching DNAs to shaping the genome
A walk through the SMC cycle: From catching DNAs to shaping the genome
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DOI：
10.1016/j.molcel.2022.04.006
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发表时间：
2022-05-05
期刊：
影响因子：
16
通讯作者：
Rowland, Benjamin D.
中科院分区：
文献类型：
--
作者：
Oldenkamp, Roel;Rowland, Benjamin D.
SMC蛋白复合物是提供染色体结构的分子机器。这些复合物在DNA元素之间架起桥梁，通过这样做在顺式中构建DNA环，并在反式中将姐妹染色单体连接在一起。我们讨论了剧烈的构象变化如何允许SMC复合物构建如此复杂的DNA结构。这些复合物的严格调控控制着基本的染色体过程，如转录、重组、修复和有丝分裂。
SMC protein complexes are molecular machines that provide structure to chromosomes. These complexes bridge DNA elements and by doing so build DNA loops in cis and hold together the sister chromatids in trans. We discuss how drastic conformational changes allow SMC complexes to build such intricate DNA structures. The tight regulation of these complexes controls fundamental chromosomal processes such as transcription, recombination, repair, and mitosis.