Neurocognitive function in schizophrenia at a 10-year follow-up: A preliminary investigation
Neurocognitive function in schizophrenia at a 10-year follow-up: A preliminary investigation
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DOI：
10.1017/s1092852900022598
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发表时间：
2005-04-01
期刊：
影响因子：
3.3
通讯作者：
Wexler, BE
中科院分区：
文献类型：
--
作者：
Kurtz, MM;Seltzer, JC;Wexler, BE
简介：大量证据表明，精神分裂症患者在发病时和治疗多年后，神经认知缺陷都很明显。关于这些缺陷在生命周期中是否或如何变化，我们知之甚少。本研究的目的是评估精神分裂症患者在10年的时间间隔内全面智商和神经认知测试表现的变化。对12名患者进行了韦氏成人智力量表修订版（Wechsler Adult Intelligence Scale-Revised）和神经心理学成套测试，其中韦氏成人智力量表修订版（Wechsler Adult Intelligence Scale-Revised）作为智力功能的测量，神经心理学成套测试包括注意力、言语和非言语记忆、语言、视觉空间功能、问题解决、和运动功能在进入研究，并在10年follow-up.Results：除了性能上的一个措施，加速运动排序，有没有显着下降，在任何措施，在10年的后续行动。结果从一个措施的持续听觉attention显示改善follow-up.Discussion：这些数据支持的神经发育模型的精神分裂症为年轻的成年人到中年患者的建议，神经认知缺陷出现之前，疾病发作或早期的过程中的疾病保持稳定，作为病人的年龄。总的来说，至少在一个精神分裂症患者亚组中，智商和特定神经认知技能的测量值在10年内没有下降。
Introduction: A wealth of evidence indicates that neurocognitive deficits are evident in patients with schizophrenia at both illness onset and after many years of treatment. Little is known regarding if or how these deficits change during the lifespan. The goal of the study was to evaluate changes in full-scale intelligence quotient and neurocognitive test performance over a 10-year interval in patients with schizophrenia.Methods: Twelve patients were administered the Wechsler Adult Intelligence Scale-Revised as a measure of intellectual function and a neuropsycshological test battery including measures of attention, verbal and nonverbal memory, language, visuospatial function, problem-solving, and motor function at entry to the study and at a 10-year follow-up.Results: With the exception of performance on a measure of speeded motor sequencing, there was no significant decline in any of the measures at 10-year follow-up. Results from a measure of sustained auditory attention showed improvement at follow-up.Discussion: These data support a neurodevelopmental model of schizophrenia for young adult to middle-age patients by suggesting that neurocognitive deficits that emerge either before disease onset or early in the course of the illness remain stable as the patient ages.Conclusion: Overall, measures of intelligence quotient as well as specific neurocognitive skills, do not decline over a 10-year period in at least a subgroup of patients with schizophrenia.