Autism symptoms in toddlers with Down syndrome: a descriptive study
Autism symptoms in toddlers with Down syndrome: a descriptive study
复制标题
DOI：
10.1111/j.1468-3148.2007.00368.x
复制
发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Rogers, Sally
中科院分区：
文献类型：
--
作者：
Hepburn, Susan;Philofsky, Amy;Rogers, Sally
背景研究表明，唐氏综合征儿童患自闭症谱系障碍的风险可能增加；然而，以前的研究没有利用全面的、最先进的诊断工具来解决自闭症和唐氏综合征的共病问题。自闭症诊断观察表(ADOS-G)和自闭症诊断访谈修订版(ADI-R)由经验丰富的临床医生实施，然后确定儿童是否出现明显的自闭症症状。结果3名儿童(15%)在两个时间点都符合自闭症谱系障碍的标准，2名儿童(10%)符合自闭症障碍的标准。文中提供了案例说明。有几个孩子表现出沟通和游戏方面的困难，但没有表现出核心社会关系方面的问题。ADOS-G单独使用时，对唐氏综合征幼儿的自闭症有过高的诊断价值。结论临床判断对唐氏综合征自闭症的诊断至关重要。年幼的孩子可能会表现出一些自闭症的迹象(特别是在交流方面)，而不会有这种障碍。与没有自闭症的同龄人相比，患有唐氏综合症和自闭症的儿童尤其具有挑战性。
Background Research suggests that children with Down syndrome may be at increased risk of having an autism spectrum disorder; however, previous studies have not utilized comprehensive, state-of-the-art diagnostic tools to address the question of comorbid autism and Down syndrome.Method Comprehensive evaluations for autism were conducted in 20 2-year-old children with Down syndrome. The Autism Diagnostic Observation Schedule-Generic (ADOS-G) and the Autism Diagnostic Interview-Revised (ADI-R) were administered by experienced clinicians, who then determined if the child presented with significant symptoms of autism. Eighteen children participated in a follow-up evaluation at age 4 years.Results Three children (15%) met criteria for an autism spectrum disorder at both time points, and two (10%) for autistic disorder. Case descriptions are provided. Several children presented with difficulties in communication and play, but did not show problems in core social relatedness. The ADOS-G, if used alone, over-identifies autism in toddlers with Down syndrome.Conclusions Clinical judgement is critical in diagnosing autism in Down syndrome. Young children may show some signs of autism (particularly in the area of communication) and not have the disorder. Children who have comorbid Down syndrome and autism are particularly challenged, relative to their peers without autism.