Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.
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DOI：
10.1186/s12968-021-00752-1
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发表时间：
2021-06-10
期刊：
影响因子：
--
通讯作者：
COVID-HEART investigators
中科院分区：
文献类型：
--
作者：
Gorecka M;McCann GP;Berry C;Ferreira VM;Moon JC;Miller CA;Chiribiri A;Prasad S;Dweck MR;Bucciarelli-Ducci C;Dawson D;Fontana M;Macfarlane PW;McConnachie A;Neubauer S;Greenwood JP;COVID-HEART investigators
尽管2019冠状病毒病（COVID-19）主要是一种呼吸系统疾病，但心肌损伤的报道越来越多，并与不良后果相关。然而，其病理生理、心肌损伤程度及临床意义尚不清楚。COVID-HEART是一项英国多中心、前瞻性、观察性、纵向队列研究，研究对象是确诊的COVID-19和肌钙蛋白升高的患者（性别特异性bbb99百分位）。基线评估将在住院康复或最近出院时进行，包括心血管磁共振（CMR）成像、生活质量（QoL）评估、心电图（ECG）、血清生物标志物和遗传学。6个月时的评估包括重复CMR、生活质量评估和6分钟步行测试（6MWT）。CMR方案包括选定患者的电影成像、T1/T2成像、主动脉扩张、晚期钆增强（LGE）和腺苷应激心肌灌注成像。这项研究的主要目的是：(1)描述肌钙蛋白升高的COVID-19患者心肌受累的程度和性质；(2)评估心脏受累和临床结果与已知的死亡危险因素（年龄、性别、种族和合并症）和遗传因素的关系；(3)评估6个月时心肌恢复的差异是否取决于人口统计学、遗传学和合并症。(4)了解6个月时康复状况对患者报告的生活质量和功能能力的影响。COVID-HEART将提供心脏受累的详细特征，以及与合并症、遗传学、患者报告的生活质量测量和功能能力相关的修复和恢复。临床试验注册：ISRCTN 58667920。注册2020年8月4日。
Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear. COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th centile). Baseline assessment will be whilst recovering in-hospital or recently discharged, and include cardiovascular magnetic resonance (CMR) imaging, quality of life (QoL) assessments, electrocardiogram (ECG), serum biomarkers and genetics. Assessment at 6-months includes repeat CMR, QoL assessments and 6-min walk test (6MWT). The CMR protocol includes cine imaging, T1/T2 mapping, aortic distensibility, late gadolinium enhancement (LGE), and adenosine stress myocardial perfusion imaging in selected patients. The main objectives of the study are to: (1) characterise the extent and nature of myocardial involvement in COVID-19 patients with an elevated troponin, (2) assess how cardiac involvement and clinical outcome associate with recognised risk factors for mortality (age, sex, ethnicity and comorbidities) and genetic factors, (3) evaluate if differences in myocardial recovery at 6 months are dependent on demographics, genetics and comorbidities, (4) understand the impact of recovery status at 6 months on patient-reported QoL and functional capacity. COVID-HEART will provide detailed characterisation of cardiac involvement, and its repair and recovery in relation to comorbidity, genetics, patient-reported QoL measures and functional capacity. Clinical Trial registration: ISRCTN 58667920. Registered 04 August 2020.
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影响因子：
37.8
作者：
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通讯作者：
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