In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents
In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents
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DOI：
10.1128/aac.00452-07
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发表时间：
2007-07-01
影响因子：
4.9
通讯作者：
Kusne, Shimon
中科院分区：
文献类型：
--
作者：
Almyroudis, Nikolaos G.;Sutton, Deanna A.;Kusne, Shimon
我们评估了217种放线菌对阿替霉素B、酮康唑、氟康唑、伊曲康唑、伏立康唑、泊沙康唑、卡泊芬净和氟胞嘧啶的体外敏感性。泊沙康唑对几个物种的显着体外活性似乎支持其报告的临床疗效。观察到小克银汉霉对阿替霉素B的敏感性降低。
We evaluated the in vitro susceptibilities of 217 zygomycetes to amphotericin B, ketoconazole, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and flucytosine. The significant in vitro activity of posaconazole against several species appears to support its reported clinical efficacy. Decreased susceptibility to amphotericin B was noted with Cunninghamella bertholletiae.