A HEPARIN-BINDING GROWTH-FACTOR SECRETED BY MACROPHAGE-LIKE CELLS THAT IS RELATED TO EGF
A HEPARIN-BINDING GROWTH-FACTOR SECRETED BY MACROPHAGE-LIKE CELLS THAT IS RELATED TO EGF
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DOI：
10.1126/science.1840698
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发表时间：
1991-02-22
期刊：
影响因子：
56.9
通讯作者：
KLAGSBRUN, M
中科院分区：
文献类型：
--
作者：
HIGASHIYAMA, S;ABRAHAM, JA;KLAGSBRUN, M
巨噬细胞样U-937细胞分泌一种22千道尔顿肝素结合生长因子，对BALB-3 T3成纤维细胞和平滑肌细胞有促有丝分裂作用，但对内皮细胞无促有丝分裂作用。 从互补DNA克隆预测的氨基酸序列表明，有丝分裂原是表皮生长因子（EGF）家族的新成员。 这种肝素结合EGF样生长因子（HB-EGF）与A-431表皮样癌细胞和平滑肌细胞上的EGF受体结合，但对平滑肌细胞来说是比EGF更有效的有丝分裂原。 HB-EGF也在培养的人巨噬细胞中表达，并可能参与巨噬细胞介导的细胞增殖。
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.