Facial pigmentation as a biomarker of carotid atherosclerosis in middle-aged to elderly healthy Japanese subjects.
Facial pigmentation as a biomarker of carotid atherosclerosis in middle-aged to elderly healthy Japanese subjects.
复制标题
面部色素沉着作为中老年健康日本受试者颈动脉粥样硬化的生物标志物。
DOI：
10.1111/srt.12223
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Sayama K.
中科院分区：
文献类型：
--
作者：
Miyawaki S;Kohara K;Kido T;Tabara Y;Igase M;Miki T;Sayama K.
背景/目的与实际年龄相比，感知年龄可能是更好的死亡率预测因子。我们已经证明，感知年龄是日本人颈动脉粥样硬化的重要生物标志物。然而，仍有待确定的皮肤参数与动脉粥样硬化。本研究的目的是分析10个面部皮肤老化参数和动脉粥样硬化之间的关系，在169中年到老年日本妇女谁participated.MethodsFacial照片下，从三个方向，使用高分辨率数码相机的无影灯。使用计算机软件分析每个受试者的数字图像，并量化皮肤老化的各种参数，如色素沉着，皱纹和肤色。颈动脉内膜中层厚度（IMT）和臂踝脉搏波速度（baPWV）作为动脉粥样硬化的指标进行测量。结果面部色素沉着与颈动脉IMT显著相关（r= 0.13，P = 0.03），即使在校正年龄后，与内脏脂肪面积也显著相关。逐步回归分析表明面部色素沉着通过内脏脂肪区与颈动脉内膜中层厚度相关。结论面部色素沉着可能是日本女性颈动脉粥样硬化的一个有用的生物标志物。
Background/purposePerceived age may be a better predictor of mortality rate than chronological age. We have demonstrated that perceived age was a significant biomarker for carotid atherosclerosis in Japanese. However, it remains to be determined which skin parameter is associated with atherosclerosis. The purpose of this study is to analyze the relationship between 10 facial skin‐aging parameters and atherosclerosis in 169 middle‐aged to elderly Japanese women who participated.MethodsFacial photographs were taken under a shadowless lamp from three directions using a high‐resolution digital camera. The digital images of each subject were analyzed using computer software and various parameters of skin aging such as pigmentation, wrinkles, and skin color were quantified. Carotid intima‐media thickness (IMT) and brachial‐ankle pulse wave velocity (baPWV) were measured as indices for atherosclerosis.ResultsFacial pigmentation showed a significant correlation with carotid IMT, even after correction for age (r= 0.13,P= 0.03), and with visceral fat area. Stepwise regression analysis indicated that facial pigmentation was associated with carotid IMT via visceral fat area.ConclusionFacial pigmentation may be a useful biomarker for carotid atherosclerosis in Japanese women.