Real-time sono-elastography in the diagnosis of diffuse liver diseases
Real-time sono-elastography in the diagnosis of diffuse liver diseases
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DOI：
10.3748/wjg.v16.i14.1720
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发表时间：
2010-04-14
影响因子：
4.3
通讯作者：
Sandulescu, Larisa
中科院分区：
文献类型：
--
作者：
Gheonea, Dan Ionut;Saftoiu, Adrian;Sandulescu, Larisa
目的：分析计算机增强弹性成像动态分析是否能够更好地表征和区分不同程度的肝纤维化。方法：研究设计具有前瞻性。连续对 132 名慢性肝病患者和健康志愿者进行了经腹超声弹性成像检查。所有检查均由两名医生完成。结果：由于方法的局限性，我们仅在73.48%的患者中获得了高质量的弹性成像信息。应用K均值聚类方法评估观察者间的诊断变异性，根据每个观察者的超声检查经验，显示出良好的变异性值。 Cohen 的 K 检验表明研究观察者之间的一致性中等（kappa = 0.4728）。此外，我们使用比较两个比例的检验（t 值，两侧检验）来比较两个观察者对患者进行聚类的方式。无论患者的真实状况如何，两位医生之间都没有统计学上的显着差异。结论：经腹部实时弹性成像无疑是描述肝脏硬度的一种非常有用的方法，尽管它在大型多中心研究中尚未得到完全测试。 (C)2010年百事登。版权所有。
AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis.METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two doctors.RESULTS: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The K-means clustering method was applied to assess the inter-observer diagnosis variability, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen's K test indicated a moderate agreement between the study observers (kappa = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients' real status.CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hardness, although it is incompletely tested in large multicenter studies. (C) 2010 Baishideng. All rights reserved.