Synthesis of phosphorylated chitosan by novel method and its characterization
Synthesis of phosphorylated chitosan by novel method and its characterization
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DOI：
10.1016/j.ijbiomac.2007.12.011
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发表时间：
2008-05-01
影响因子：
8.2
通讯作者：
Tamura, H.
中科院分区：
文献类型：
--
作者：
Jayakumar, R.;Nagahama, H.;Tamura, H.
壳聚糖是一种天然高分子材料，无毒，生物相容性好，可生物降解。壳聚糖的化学改性产生新的双功能材料，最终将带来新的性能取决于引入的基团的性质。本文采用H_3PO_4/P_2O_5/Et_3PO_4/正己醇法制备了磷酸化壳聚糖（P-chitosan）。采用本方法，得到了高收率和高取代度的产品。用FT IR、13 C NMR、31 P NMR、元素分析、XRD、TGA、DTA和SEM等方法对所制备的P-壳聚糖（DS-1.18）进行了表征。磷酸化后，聚合物的溶解性得到改善。P-壳聚糖的热稳定性和结晶度低于壳聚糖。这是由于磷酸化。(c)2008 Elsevier B. V.保留所有权利。
Chitosan a natural based polymer is non-toxic, biocompatible and biodegradable. Chemical modification of chitosan to generate new bifunctional materials and finally would bring new properties depending on the nature of the group introduced. In our present study, we prepared phosphorylated chitosan (P-chitosan) by using H3PO4/P2O5/Et3PO4/hexanol method. From our present method, we got high yield and high degree of substitution (DS). The prepared P-chitosan (DS-1.18) was characterized by FT IR, C-13 NMR, P-31 NMR, elemental, XRD, TGA, DTA and SEM studies. After the phosphorylation, the solubility of the polymer was improved. The P-chitosan showed less thermal stability and crystallinity than the chitosan. It was due to the phosphorylation. (c) 2008 Elsevier B.V. All rights reserved.