Electrochemical Gold(III) Sensor with High Sensitivity and Tunable Dynamic Range.
Electrochemical Gold(III) Sensor with High Sensitivity and Tunable Dynamic Range.
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DOI：
10.1021/acs.analchem.5b03868
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发表时间：
2016-02
影响因子：
7.4
通讯作者：
Yao Wu;R. Lai
中科院分区：
文献类型：
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作者：
Yao Wu;R. Lai
我们报道了一种用于检测Au（III）的灵敏、特异和选择性电化学离子（E-ION）传感器的设计和制造。信号传导机制是基于Au（III）和腺嘌呤之间的相互作用;这些复合物的形成使亚甲蓝（MB）修饰的寡聚腺嘌呤探针刚性化，导致MB信号的浓度依赖性降低。传感器的动态范围可以通过简单地改变DNA探针的长度（6个（A6）或12个（A12）腺嘌呤）来调整。独立的探针长度，这两个传感器已被证明是敏感的，与50和20 nM的A6和A12传感器的检测限，分别。通过进一步优化，这种传感策略可能为分析Au（III）提供一种有前途的方法。
We report the design and fabrication of a sensitive, specific, and selective electrochemical ion (E-ION) sensor for detection of Au(III). The signaling mechanism is based on the interactions between Au(III) and adenine; formation of these complexes rigidifies the methylene blue (MB)-modified oligoadenine probes, resulting in a concentration-dependent reduction in the MB signal. The dynamic range of the sensor can be tuned by simply changing the length of the DNA probe (six (A6) or 12 (A12) adenines). Independent of the probe length, both sensors have demonstrated to be sensitive, with a limits of detection of 50 and 20 nM for the A6 and A12 sensors, respectively. With further optimization, this sensing strategy may offer a promising approach for analyzing Au(III).