Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees
Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees
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DOI：
10.1016/j.exger.2004.02.010
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发表时间：
2004-05-01
影响因子：
3.9
通讯作者：
Omholt, SW
中科院分区：
文献类型：
--
作者：
Amdam, GV;Simoes, ZLP;Omholt, SW
寿命可塑性的一个突出例子是在蚂蚁和蜜蜂等社会性昆虫中看到的，不同的种姓可能会显示出不同的衰老模式。特别是，蜜蜂提供了一个有趣的例子，说明环境对衰老速度的控制。蜜蜂工人显示劳动力的时间分工，年轻的蜜蜂（或“蜂巢”）在巢内执行任务，年长的蜜蜂觅食花蜜，花粉和水。当蜜蜂从蜂巢蜜蜂转换到觅食阶段时，它们的细胞防御机制通过功能性血细胞（免疫细胞）数量的急剧减少而下调。这项研究的文件，蛋黄前体卵黄蛋白原可能参与了一个监管途径，控制观察到的蜜蜂觅食体细胞维护功能的下降。糖脂蛋白卵黄蛋白原和免疫功能之间的关联以前没有任何生物体的报道。蜜蜂工蜂是功能性不育的，通过表达保幼激素，一种成年昆虫中关键的促性腺激素，它们的卵黄蛋白原水平受到与其他蜜蜂的社会互动的影响。因此，我们的研究结果表明，在细胞免疫系统的维护方面，衰老的蜜蜂工人是社会控制。(C)2004爱思唯尔公司All rights reserved.
A striking example of plasticity in life span is seen in social insects such as ants and bees, where different castes may display distinct ageing patterns. In particular, the honeybee offers an intriguing illustration of environmental control on ageing rate. Honeybee workers display a temporal division of labour where young bees (or 'hive bees') perform tasks within the brood nest, and older bees forage for nectar, pollen propolis and water. When bees switch from the hive bee to the forager stage, their cellular defence machinery is down-regulated by a dramatic reduction in the number of functioning haemocytes (immunocytes). This study documents that the yolk precursor vitellogenin is likely to be involved in a regulatory pathway that controls the observed decline in somatic maintenance function of honeybee foragers. An association between the glyco-lipoprotein vitellogenin and immune function has not previously been reported for any organism. Honeybee workers are functionally sterile, and via the expression of juvenile hormone, a key gonotrophic hormone in adult insects, their vitellogenin levels are influenced by social interactions with other bees. Our results therefore suggest that in terms of maintenance of the cellular immune system, senescence of the honeybee worker is under social control. (C) 2004 Elsevier Inc. All rights reserved.