Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices
Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices
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DOI：
10.1167/iovs.14-15072
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发表时间：
2014-10-01
影响因子：
4.4
通讯作者：
Goebel, Winfried
中科院分区：
文献类型：
--
作者：
Matlach, Juliane;Wagner, Martin;Goebel, Winfried
目的.比较两种光谱域光学相干断层扫描（SD-OCT）测量青光眼患者、高眼压患者、特发性和非典型帕金森病患者以及健康对照者黄斑区视网膜内层和视乳头周围视网膜神经纤维层（pRNFL）厚度的差异。146名参与者的共171只眼使用Cirrus HD-OCT进行了成功的pRNFL和黄斑扫描并自动测量了神经节细胞层+内丛状层（GCL-IPL）或使用RTVue-100进行了视网膜神经纤维层+ GCL-IPL（RNFL-GCL-IPL）。将黄斑RNFL添加到Cirrus测量的GCL-IPL厚度中，并与相应Cirrus扇区中RTVue的RNFL-GCL-IPL厚度进行比较。计算组内相关系数（ICC）以确定三次连续测量的重复性; ICC和Bland-Altman分析以评估OCT之间的一致性; Pearson相关系数以评估线性相关性的强度。平均黄斑RNFL-GCL-IPL厚度测量的重复性非常好，Cirrus的ICC为0.998，RTVue为0.995。平均pRNFL厚度测量的重复性也很好。两种仪器的测量结果具有良好的一致性，黄斑RNFL-GCL-IPL的ICC值范围为0.844 - 0.862，pRNFL厚度的ICC值范围为0.718 - 0.958。对于两种OCT设备，pRNFL和黄斑RNFL-GCL-IPL厚度的测量具有高度的可重复性。尽管两种OCT设备的测量结果之间存在高度相关性，且ICC值从一般到极好，代表了两种设备测量结果的高度一致性，但RTVue测量的黄斑RNFL-GCL-IPL和pRNFL厚度较厚。
PURPOSE. To compare measurement of macular inner retina and peripapillary retinal nerve fiber layer (pRNFL) thickness using two spectral-domain optical coherence tomography (SD-OCT) devices in glaucoma patients, patients with ocular hypertension, idiopathic and atypical Parkinson disease, and healthy controls.METHODS. A total of 171 eyes of 146 participants underwent successful pRNFL and macular scanning and automated measurement of ganglion cell layer + inner plexiform layer (GCL-IPL) using Cirrus HD-OCT or retinal nerve fiber layer + GCL-IPL (RNFL-GCL-IPL) using RTVue-100. Macular RNFL was added to the GCL-IPL thickness measured by Cirrus and was compared to the RNFL-GCL-IPL thickness of the RTVue in the corresponding Cirrus sectors. Intraclass correlation coefficient (ICC) was calculated to determine repeatability of three consecutive measurements; ICC and Bland-Altman analysis to assess agreement between OCTs; Pearson's correlation coefficient to assess strength of linear correlation.RESULTS. Repeatability of average macular RNFL-GCL-IPL thickness measurement was excellent with an ICC of 0.998 for Cirrus and 0.995 for RTVue. Repeatability was also good for average pRNFL thickness measurements. Both instruments demonstrated a good consistency in measurements with ICC values ranging from 0.844 to 0.862 for macular RNFL-GCL-IPL and 0.718 to 0.958 for pRNFL thickness.CONCLUSIONS. Measurement of pRNFL and macular RNFL-GCL-IPL thickness has a high degree of repeatability for both OCT devices. Despite a high correlation between measurements of the two OCT devices and fair to excellent ICC values representing a high consistency in the measurements of the two devices, RTVue measured a thicker macular RNFL-GCL-IPL and pRNFL thickness.