Retinal Thickness in People with Diabetes and Minimal or No Diabetic Retinopathy: Heidelberg Spectralis Optical Coherence Tomography
Retinal Thickness in People with Diabetes and Minimal or No Diabetic Retinopathy: Heidelberg Spectralis Optical Coherence Tomography
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DOI：
10.1167/iovs.12-10290
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发表时间：
2012-12-01
影响因子：
4.4
通讯作者：
Nielsen, Jared S.
中科院分区：
文献类型：
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作者：
Chalam, Kakarla V.;Bressler, Susan B.;Nielsen, Jared S.
目的。使用 Heidelberg Spectralis 光学相干断层扫描 (OCT) 评估患有糖尿病但视网膜病变轻微或无视网膜病变的患者的黄斑厚度。方法。在一项平均视网膜厚度的多中心横断面研究中，对 Spectralis OCT 的九个标准 OCT 子视野、跨越直径 6 毫米的区域、中心点和视网膜总体积进行了评估。评估中心亚区（CSF）厚度与人口统计和临床因素的关联。还对每位参与者进行了 Stratus OCT 扫描。结果。该分析包括 122 只患有糖尿病的眼睛（122 名参与者），临床检查中没有（n = 103）或轻微糖尿病性视网膜病变（n = 19）且没有黄斑视网膜增厚。平均CSF厚度为270+/-24μm。相对于女性，男性的中央亚区厚度显着更大（平均 278 +/- 23 μm vs. 262 +/- 22 μm，P < 0.001）。调整性别后，没有发现其他因素与脑脊液厚度显着相关（P > 0.10）。平均 Stratus OCT CSF 厚度为 199 +/- 24 μm。结论。在没有视网膜病变或患有轻微非增殖性视网膜病变和正常黄斑结构的糖尿病患者中，使用 Heidelberg Spectralis OCT 测量的平均脑脊液厚度比 Stratus OCT 厚约 70 μm。男性脑脊液厚度值≥320μm，女性脑脊液厚度值>=305μm（类似于高于该标准队列平均值的2个标准差）被建议作为性别特异性厚度水平，以合理确定使用Spectralis测量存在涉及脑脊液的糖尿病性黄斑水肿。 （投资眼科可见科学。2012 年；53：8154-8161）DOI：10.1167/iovs.12-10290
PURPOSE. To evaluate macular thickness in people with diabetes but minimal or no retinopathy using Heidelberg Spectralis optical coherence tomography (OCT).METHODS. In a multicenter, cross-sectional study of mean retinal thickness, on Spectralis OCT in the nine standard OCT subfields, spanning a zone with 6-mm diameter, center point, and total retinal volume were evaluated. Central subfield (CSF) thickness was evaluated for association with demographic and clinical factors. Stratus OCT scans also were performed on each participant.RESULTS. The analysis included 122 eyes (122 participants) with diabetes and no (n = 103) or minimal diabetic retinopathy (n = 19) and no macular retinal thickening on clinical exam. Average CSF thickness was 270 +/- 24 mu m. Central subfield thickness was significantly greater in males relative to females (mean 278 +/- 23 mu m vs. 262 +/- 22 mu m, P < 0.001). After adjusting for gender, no additional factors were found to be significantly associated with CSF thickness (P > 0.10). Mean Stratus OCT CSF thickness was 199 +/- 24 mu m.CONCLUSIONS. Mean CSF thickness is approximately 70 mu m thicker when measured with Heidelberg Spectralis OCT as compared with Stratus OCT among individuals with diabetes in the absence of retinopathy or with minimal nonproliferative retinopathy and a normal macular architecture. CSF thickness values >= 320 mu m for males and 305 mu m for females (similar to 2 SDs above the average for this normative cohort) are proposed as gender-specific thickness levels to have reasonable certainty that diabetic macular edema involving the CSF is present using Spectralis measurements. (Invest Ophthalmol Vis Sci. 2012; 53: 8154-8161) DOI:10.1167/iovs.12-10290