Associations of Behavioral Problems and White Matter Properties of the Cerebellar Peduncles in Boys and Girls Born Full Term and Preterm.
Associations of Behavioral Problems and White Matter Properties of the Cerebellar Peduncles in Boys and Girls Born Full Term and Preterm.
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足月和早产男孩和女孩的行为问题与小脑脚白质特性的关联。
DOI：
10.1007/s12311-022-01375-7
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Feldman,HeidiM
中科院分区：
文献类型：
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作者：
Hosoki,Machiko;Bruckert,Lisa;Borchers,LaurenR;Marchman,VirginiaA;Travis,KatherineE;Feldman,HeidiM
越来越多的证据表明，小脑的作用包括行为的调节;小脑损伤可能导致行为问题。行为问题因性别而异：内化问题在女孩中更常见，而外化问题在男孩中更常见。早产儿（PT）的行为问题也高于足月儿（FT）。本研究探讨了8岁儿童的内化和外化问题与性别、出生组、小脑三个脚（上级、中级和下级）的各向异性分数（FA）以及这些预测变量之间的相互作用。参与者（N= 78）包括44名男孩（28名PT）和34名女孩（15名PT）。我们通过标准化的父母报告和FA小脑脚使用确定性纤维束成像评估行为问题。与FT出生的儿童相比，PT出生的儿童的内化问题更高（p= 0.032）;性别和出生组别的相互作用显着（p= 0.044）。当考虑小脑脚的平均道FA的行为问题的贡献，有一个显着的相互作用的性别和平均道FA的小脑下脚（ICP）与内化问题，斜率为负的女孩（p= 0.020），但不是在男孩。在男孩中，内化问题仅与早产儿的平均径FA ICP相关（p= 0.010）。我们没有发现其他重要的协会有助于内化或外化的问题。因此，我们发现性别二态性和出生组的差异，在关联的白色物质指标的颅内压和内在化的问题，在学龄儿童。研究结果告知理论的起源内化的行为问题，在童年中期，并可能建议在学龄期的治疗方法。
Accumulating evidence suggests that the role of cerebellum includes regulation of behaviors; cerebellar impairment may lead to behavioral problems. Behavioral problems differ by sex: internalizing problems are more common in girls, externalizing problems in boys. Behavioral problems are also elevated in children born preterm (PT) compared to children born full term (FT). The current study examined internalizing and externalizing problems in 8-year-old children in relation to sex, birth-group, fractional anisotropy (FA) of the three cerebellar peduncles (superior, middle, and inferior), and interactions among these predictor variables. Participants (N= 78) were 44 boys (28 PT) and 34 girls (15 PT). We assessed behavioral problems via standardized parent reports and FA of the cerebellar peduncles using deterministic tractography. Internalizing problems were higher in children born PT compared to children born FT (p= .032); the interaction of sex and birth-group was significant (p= .044). When considering the contribution of the mean-tract FA of cerebellar peduncles to behavioral problems, there was a significant interaction of sex and mean-tract FA of the inferior cerebellar peduncle (ICP) with internalizing problems; the slope was negative in girls (p= .020) but not in boys. In boys, internalizing problems were only associated with mean-tract FA ICP in those born preterm (p= .010). We found no other significant associations contributing to internalizing or externalizing problems. Thus, we found sexual dimorphism and birth-group differences in the association of white matter metrics of the ICP and internalizing problems in school-aged children. The findings inform theories of the origins of internalizing behavioral problems in middle childhood and may suggest approaches to treatment at school age.