The dynamics of HMG protein-chromatin interactions in living cells.
The dynamics of HMG protein-chromatin interactions in living cells.
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DOI：
10.1139/o08-110
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Bustin M
中科院分区：
文献类型：
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作者：
Gerlitz G;Hock R;Ueda T;Bustin M
核蛋白和染色质之间的动态相互作用导致了对调节信号做出适当反应所必需的功能可塑性。在这里，我们审查的高迁移率族蛋白（HMG），一个丰富的和普遍存在的染色质结合蛋白在活细胞中的超家族的染色质相互作用的调节因素。HMG是高度移动的，并以高度动态的方式与染色质纤维相互作用，作为蛋白质网络的一部分。影响HMG与染色质结合的主要因素是在单个核小体水平上起作用的。这些因素包括HMG的结构特征，与其他染色质结合蛋白竞争核小体结合位点，与蛋白质伴侣形成复合物，以及蛋白质或染色质结合位点的翻译后修饰。HMG蛋白和染色质之间相互作用的多功能调节在建立细胞表型的过程中起作用。
The dynamic interaction between nuclear proteins and chromatin leads to the functional plasticity necessary to mount adequate responses to regulatory signals. Here, we review the factors regulating the chromatin interactions of the high mobility group proteins (HMGs), an abundant and ubiquitous superfamily of chromatin-binding proteins in living cells. HMGs are highly mobile and interact with the chromatin fiber in a highly dynamic fashion, as part of a protein network. The major factors that affect the binding of HMGs to chromatin are operative at the level of the single nucleosome. These factors include structural features of the HMGs, competition with other chromatin-binding proteins for nucleosome binding sites, complex formation with protein partners, and post-translational modifications in the protein or in the chromatin-binding sites. The versatile modulation of the interaction between HMG proteins and chromatin plays a role in processes that establish the cellular phenotype.