The connectome of the adult Drosophila mushroom body provides insights into function.
The connectome of the adult Drosophila mushroom body provides insights into function.
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DOI：
10.7554/elife.62576
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发表时间：
2020-12-14
期刊：
影响因子：
7.7
通讯作者：
Rubin GM
中科院分区：
文献类型：
--
作者：
Li F;Lindsey JW;Marin EC;Otto N;Dreher M;Dempsey G;Stark I;Bates AS;Pleijzier MW;Schlegel P;Nern A;Takemura SY;Eckstein N;Yang T;Francis A;Braun A;Parekh R;Costa M;Scheffer LK;Aso Y;Jefferis GS;Abbott LF;Litwin-Kumar A;Waddell S;Rubin GM
从突触水平的连接图中对神经元电路进行的计算进行推断是神经科学中一个新兴的机会。蘑菇体(MB)具有保守的神经元结构、最近完成的致密连接以及对其在学习、记忆和活动调节中的作用的广泛实验研究，因此非常适合开发和测试这种方法。在这里，我们确定了果蝇MB回路的新成分，包括广泛的视觉输入和MB输出神经元(MBON)，这些神经元直接连接到下行神经元。我们在感觉输入中发现了意想不到的结构，在不同感觉模式的信息传输到MBON中，以及在多巴胺能神经元(DAN)对这种传输的调制中。我们将深入了解用于集成MB输出的电路、MB和中央复合体之间的连接以及DAN的输入，包括来自MBON的反馈。我们的结果为进一步的理论和实验工作奠定了基础。
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory, and activity regulation. Here, we identify new components of the MB circuit in Drosophila, including extensive visual input and MB output neurons (MBONs) with direct connections to descending neurons. We find unexpected structure in sensory inputs, in the transfer of information about different sensory modalities to MBONs, and in the modulation of that transfer by dopaminergic neurons (DANs). We provide insights into the circuitry used to integrate MB outputs, connectivity between the MB and the central complex and inputs to DANs, including feedback from MBONs. Our results provide a foundation for further theoretical and experimental work.