CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells.
CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells.
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CD52 作为具有调节作用的 T 细胞的标记物和效应分子：新型调节性 T 细胞的鉴定。
DOI：
10.1038/cmi.2013.38
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发表时间：
2013
影响因子：
24.1
通讯作者：
Samten,Buka
中科院分区：
文献类型：
--
作者：
Samten,Buka
免疫反应的调节是有效清除病原体的关键。有效的免疫应答对于预防癌症和自身免疫性疾病的发展以及维持体内平衡也是必要的。虽然胸腺是在T细胞成熟期间调节自身耐受性的免疫应答的中枢淋巴器官，但外周成熟免疫细胞的正常功能仍然需要调节性免疫细胞。调节细胞是免疫细胞的亚群，其抑制其他免疫细胞响应抗原刺激的增殖和细胞因子产生。尽管在几乎所有主要的免疫细胞群体中已经鉴定出具有调节功能的细胞，但调节性T细胞仍然是占主导地位且研究最深入的类型。已经鉴定了几种类型的调节性T细胞，包括CD4+CD25+ T调节性细胞（TCR4），其也对Foxp3（Treg发育的主调节因子）呈阳性。1
Regulation of immune responses is central to an effective clearance of pathogens. An effective immune response is also necessary for preventing the development of cancer and autoimmune diseases and for maintaining homeostasis. Although the thymus is the central lymphoid organ that regulates immune responses for self-tolerance during the maturation of T cells, regulatory immune cells are still required for the proper functioning of mature immune cells in the periphery. Regulatory cells are a subpopulation of immune cells that suppress proliferation and cytokine production by other immune cells in response to antigenic stimulation. Although cells with regulatory functions have been identified in almost all of the major immune cell populations, regulatory T cells are still the dominant and most intensely studied type. Several types of regulatory T cells have been identified, including CD4+CD25+ T regulatory cells (Tregs), which are also positive for Foxp3, the master regulator of Treg development. 1