Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3'-quinoline] derivatives.
Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3'-quinoline] derivatives.
复制标题
DOI：
10.1039/d0cc06645a
复制
发表时间：
2020-11
影响因子：
4.9
通讯作者：
Jingjing Zhang;Wentao Xu;Yi Qu;Yuxiu Liu;Yongqiang Li;Hongjian Song;Qingmin Wang
中科院分区：
文献类型：
--
作者：
Jingjing Zhang;Wentao Xu;Yi Qu;Yuxiu Liu;Yongqiang Li;Hongjian Song;Qingmin Wang
在此，我们报告的第一个协议，可见光诱导的自由基异氰化物插入3-（2-异氰基苄基）-吲哚和溴二氟乙酸酯或溴二氟乙酰胺之间的反应。该方法具有较好的官能团耐受性和较宽的底物范围，是合成二氟甲基螺[吲哚-3，3 '-喹啉]衍生物的有效途径。
Herein, we report the first protocol for visible-light-induced radical isocyanide insertion reactions between 3-(2-isocyanobenzyl)-indoles and bromodifluoroacetates or bromodifluoroacetamides. The protocol, which has good functional group tolerance and a broad substrate scope, constitutes an efficient and general route to difluoromethylated spiro[indole-3,3'-quinoline] derivatives.