The role of EMT and MET in cancer dissemination.
The role of EMT and MET in cancer dissemination.
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DOI：
10.3109/03008207.2015.1060970
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发表时间：
2015
影响因子：
2.9
通讯作者：
Bielenberg DR
中科院分区：
文献类型：
--
作者：
Banyard J;Bielenberg DR
转移性癌细胞是致命的。了解支持良性向恶性进展转化的分子机制是治疗这些异质性和耐药肿瘤的关键。上皮-间充质转化（EMT）是一种保守的细胞程序，改变细胞的形状，粘附和运动。向更间充质样表型的转变可以促进肿瘤细胞向周围血管的内渗和迁移到新的器官，但可能不是外渗或定植到该环境中所必需的。另一方面，淋巴传播可能不需要EMT。本文综述了肿瘤细胞通过microRNA促进EMT/MET和通过外泌体准备转移前小生境的模式的新数据。
Metastatic cancer cells are lethal. Understanding the molecular mechanisms that bolster the conversion from benign to malignant progression is key to treating these heterogeneous and resistant neoplasms. The epithelial-mesenchymal transition (EMT) is a conserved cellular program that alters cell shape, adhesion, and movement. The shift to a more mesenchymal-like phenotype can promote tumor cell intravasation of surrounding blood vessels and emigration to a new organ, yet may not be necessary for extravasation or colonization into that environment. Lymphatic dissemination, on the other hand, may not require EMT. This review presents emerging data on the modes by which tumor cells promote EMT/MET via microRNA and prepare the pre-metastatic niche via exosomes.