Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp CHQ-64
Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp CHQ-64
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DOI：
10.1021/ol301396h
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发表时间：
2012-07-06
期刊：
影响因子：
5.2
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Che, Qian;Zhu, Tianjiao;Li, Dehai
从一株来源于芦苇根际土壤的放线菌Streptomycessp. CHQ-64中分离得到一个具有稠合五环骨架的杂合类异戊二烯化合物IndotertineA（1），以及两个相关的杂合类异戊二烯化合物drimentines F（2）和G（3）。通过谱学、X射线单晶衍射和TDDFT ECD计算确定了它们的结构。Drimentines G（3）对人癌细胞系显示出强的细胞毒性，IC 50低至1.01 μ M，而1和2没有显示出显著的活性。
Indotertine A (1), a hybrid isoprenoid with a condensed pentacyclic skeleton, together with two related hybrid isoprenoids, drimentines F (2) and G (3), were isolated from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. Their structures including absolute configurations were elucidated by spectroscopic methods, X-ray single crystal diffraction analysis, and TDDFT ECD calculations. Drimentines G (3) showed strong cytotoxicity against human cancer cells lines with IC50's down to 1.01 mu M, while 1 and 2 showed no significant activity.