Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
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DOI：
10.1210/jc.2003-031562
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发表时间：
2004-05-01
影响因子：
5.8
通讯作者：
Chrousos, GP
中科院分区：
文献类型：
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作者：
Vgontzas, AN;Zoumakis, E;Chrousos, GP
人类的总睡眠限制与白天嗜睡增加、表现下降和激素/代谢紊乱有关。模拟真实的生活的轻度慢性睡眠限制的影响尚不清楚。为了评估从8到6小时/夜的适度睡眠限制1周的影响，25名年轻，健康，正常睡眠者（12名男性和13名女性）在睡眠实验室连续12个晚上进行了研究。限制睡眠1 wk后，尽管受试者夜间睡眠较深，但受试者的嗜睡（多次睡眠潜伏期测试）明显增加，精神警觉性测试的四个主要变量的表现也变差（均P < 0.01）。此外，在两种性别中，24小时IL-6的分泌增加了0.8 +/- 0.3 pg/ml（P < 0.05），而TNF α仅在男性中增加。此外，睡眠限制后皮质醇分泌峰值低于基线水平，男性（55.18 +/- 24.83 nmol/L; P < 0.05）的差异大于女性（35.87 +/- 24.83 nmol/L; P < 0.16）。我们的结论是，在年轻男性和女性中，适度的睡眠不足与显著的嗜睡、精神表现受损和促炎细胞因子分泌增加有关。考虑到这些行为和身体变化与健康、福祉和公共安全的潜在联系，睡眠或部分睡眠是可选的这一想法应该谨慎对待。
Total sleep restriction in humans is associated with increased daytime sleepiness, decreased performance, and hormonal/metabolic disturbances. The effects of mild chronic sleep restriction that mimic real life are not known. To assess the effects of modest sleep restriction from 8 to 6 h/night for 1 wk, 25 young, healthy, normal sleepers ( 12 men and 13 women) were studied for 12 consecutive nights in the sleep laboratory. After 1 wk of sleep restriction, although subjects' nighttime sleep was deeper, subjects were significantly sleepier ( multiple sleep latency test) and performed worse in four primary variables of psychomotor vigilance test (both P < 0.01). Furthermore, 24-h secretion of IL-6 was increased by 0.8 +/- 0.3 pg/ml (P < 0.05) in both sexes, whereas TNFalpha was increased only in men. Also, the peak cortisol secretion was lower after sleep restriction than at baseline, and this difference was stronger in men (55.18 +/- 24.83 nmol/liter; P < 0.05) than in women (35.87 +/- 24.83 nmol/liter; P < 0.16). We conclude that in young men and women, modest sleep loss is associated with significant sleepiness, impairment of psychomotor performance, and increased secretion of proinflammatory cytokines. Given the potential association of these behavioral and physical alterations with health, well-being, and public safety, the idea that sleep or parts of it are optional should be regarded with caution.