Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
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DOI：
10.1016/j.canlet.2007.07.018
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发表时间：
2007-11-18
期刊：
影响因子：
9.7
通讯作者：
Lung, Maria Li
中科院分区：
文献类型：
--
作者：
Lo, Paulisally Hau Yi;Xie, Dan;Lung, Maria Li
肿瘤抑制基因的表达减少或丢失在许多癌症中起关键作用。本研究旨在探讨RASSF 1A在食管鳞状细胞癌（ESCC）和鼻咽癌（NPC）发病机制中的作用。我们用RT-PCR和组织芯片免疫组化染色检测RASSF 1A转录本和蛋白在肿瘤组织中的表达下调。RASSF 1A表达下调与WHO分级、肿瘤状态和淋巴结转移显著相关，表明其可能作为临床标本的生物标志物。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens. (C) 2007 Elsevier Ireland Ltd. All rights reserved.