A divergent approach to apoptolidin and FD-891: asymmetric preparation of a common intermediate
A divergent approach to apoptolidin and FD-891: asymmetric preparation of a common intermediate
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DOI：
10.1016/s0040-4039(03)01173-0
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发表时间：
2003-06-30
影响因子：
1.8
通讯作者：
Loh, TP
中科院分区：
文献类型：
--
作者：
Chng, SS;Xu, J;Loh, TP
生物活性的山梨内酯和FD-891在其大环核心上具有相似的结构。介绍了这两种大环内酯类化合物全合成中共同中间体的不对称制备方法。采用改进的Masuyama锡烯丙基化反应控制中间体合成过程中的相对立体化学。(C)2003爱思唯尔科学有限公司。保留所有权利。
Biologically active Apoptolidin and FD-891 have structural similarity in their macrocyclic cores. Asymmetric preparation of a common intermediate in the total synthesis of these two macrolides is presented. A modified Masuyama Sn-allylation was employed to control the relative stereochemistry in the synthesis of the intermediate. (C) 2003 Elsevier Science Ltd. All rights reserved.