Serum concentration of anti-Mullerian hormone is not associated with semen quality
Serum concentration of anti-Mullerian hormone is not associated with semen quality
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DOI：
10.1111/andr.12456
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发表时间：
2018-03-01
期刊：
影响因子：
4.5
通讯作者：
Jorgensen, N.
中科院分区：
文献类型：
--
作者：
Aksglaede, L.;Olesen, I. A.;Jorgensen, N.
精液质量受损在西方国家很常见，是高达 50% 的夫妇不孕不育的主要原因或促成原因。男性因素不育主要根据世界卫生组织2010年指南通过精液样本检查来确定。 AMH 通过 AMH II 型受体的直接作用而具有自分泌和旁分泌特性，因此被认为参与精子发生。我们旨在通过一项横断面研究来研究 AMH 血清浓度与精液质量之间的关联，该研究纳入了来自普通人群的 970 名年轻丹麦男性。所有参与者提供精液样本，抽取血液样本，进行体检，并回答包括生活方式和病史信息的调查问卷。生殖激素的血清浓度[AMH、黄体生成素（LH）、卵泡刺激素（FSH）、总睾酮（T）、计算游离T、雌二醇（E2）和抑制素B]和精液参数（精液量、精子浓度以及活动和形态正常的百分比）精子）进行了测定。我们发现血清 AMH 与精液质量之间没有关联，除了正常形态百分比较低且 AMH 较高的显着趋势（p=0.011）。 AMH 四分位数与血清抑制素 B 呈正相关 (p
Impaired semen quality is frequent in Western countries and is the main reason or contributing reason in up to 50% of cases of couple infertility. Male factor infertility is mainly determined by examination of semen samples according to the World Health Organization's 2010 guidelines. AMH has both autocrine and paracrine properties through a direct effect via the AMH type II receptor and is therefore thought to be involved in spermatogenesis. We aimed to study the association between the serum concentration of AMH and semen quality in a cross-sectional study including 970 young Danish men from the general population. All participants provided a semen sample, had a blood sample drawn, underwent a physical examination, and answered a questionnaire including information on lifestyle and medical history.Serum concentrations of reproductive hormones [AMH, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), calculated free T, oestradiol (E2) and inhibin B] and semen parameters (semen volume, sperm concentration, and percentages of motile and morphologically normal spermatozoa) were determined. We found no association between serum AMH and semen quality, except for a significant (p=0.011) trend for lower percentage of normal morphology with higher AMH. AMH quartile was positively associated with serum inhibin B (p