Chronic chorioamnionitis: A clinicopathologic and immunohistochemical study
Chronic chorioamnionitis: A clinicopathologic and immunohistochemical study
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DOI：
10.1016/s0046-8177(98)90016-8
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发表时间：
1998-12-01
期刊：
影响因子：
3.3
通讯作者：
Qureshi, F
中科院分区：
文献类型：
--
作者：
Jacques, SM;Qureshi, F
胎膜淋巴细胞性炎症是不常见的，被称为慢性绒毛膜炎。本文报告31例胎盘慢性绒毛膜炎的临床病理及免疫组化结果。最常见的组织病理学相关性是病因不明的慢性绒毛炎，在31个胎盘中有22个（71%）被确定。慢性绒毛膜炎的严重程度与慢性绒毛膜炎的严重程度无关。其他胎盘发现包括2例慢性绒毛间炎，5例胎儿血管血栓形成，4例出血性血管内膜炎，3例蜕膜慢性血管炎，1例动脉粥样硬化。母亲病史包括6例妊娠高血压和1例糖尿病。12名婴儿为早产，5名胎儿宫内发育迟缓。无新生儿败血症或死亡。慢性绒毛膜炎区域的免疫组化染色显示CD 3+和CD 8+细胞数量适中，CD 4+细胞数量较少。CD 20+和CD 56+细胞很少或不存在。慢性绒毛膜炎通常与病因不明的慢性绒毛炎相关，具有相似的临床相关性，可能有相关的原因，可能是免疫学原因。《人文哲学》29：1457-1461。版权所有（C）1998由W.B.桑德斯公司
Lymphocytic inflammation of the fetal membranes is unusual and has been termed chronic chorioamnionitis. We report the clinicopathologic and immunohistochemical findings in 31 placentas with chronic chorioamnionitis. The most common histopathologic association was chronic villitis of unknown etiology, which was identified in 22 (71%) of the 31 placentas. The severity of the chronic villitis did not correlate with the severity of chronic chorioamnionitis. Additional placental findings included chronic intervillositis in two, fetal vessel thrombosis in five, hemorrhagic endovasculitis in four, decidual chronic vasculitis in three, and atherosis in one. Maternal history included pregnancy-induced hypertension in six and diabetes in one. Twelve infants were preterm, and five had intrauterine growth retardation. There was no neonatal sepsis or death. Immunohistochemical staining in areas of chronic chorioamnionitis showed CD3+ and CD8+ cells present in moderate numbers, and CD4+ cells in smaller numbers. CD20+ and CD56+ cells were rare or absent. Chronic chorioamnionitis is commonly associated with chronic villitis of unknown etiology, shares similar clinical associations, and may have a related cause, possibly immunologic. HUM PATHOL 29:1457-1461. Copyright (C) 1998 by W.B. Saunders Company.